1-Acetyl-β-carboline
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1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin.
For research use only. We do not sell to patients.
- Purity: 97.04%
- CAS No.: 50892-83-6
- Formula: C13H10N2O
- Molecular Weight:210.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
>40 μM
Compound: 41
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Cytotoxicity activity against human A549 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay
Cytotoxicity activity against human A549 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay
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[PMID: 21316977] |
| A549 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 21977916] |
| DU-145 | GI50 |
>40 μM
Compound: 41
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Cytotoxicity activity against human DU145 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay
Cytotoxicity activity against human DU145 cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay
|
[PMID: 21316977] |
| DU-145 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 21977916] |
| HeLa | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 21977916] |
| HT-22 | IC50 |
>100 μM
Compound: 31
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Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 36876904] |
| KB | GI50 |
>40 μM
Compound: 41
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Cytotoxicity activity against human KB cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay
Cytotoxicity activity against human KB cells assessed as growth inhibition at 10 ug/ml after 72 hrs sulforhodamine B assay
|
[PMID: 21316977] |
| MCF7 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 21977916] |
| MDA-MB-231 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 21977916] |
| NCI-H460 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
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[PMID: 21977916] |
| Neutrophil | IC50 |
>30 μM
Compound: 41
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Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
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[PMID: 21316977] |
| Neutrophil | IC50 |
5.03 μM
Compound: 41
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Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
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[PMID: 21316977] |
| SMMC-7721 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
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[PMID: 21977916] |
| SW1990 | IC50 |
>50 μM
Compound: 7
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Cytotoxicity against human SW1990 cells after 48 hrs by MTT assay
Cytotoxicity against human SW1990 cells after 48 hrs by MTT assay
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[PMID: 21977916] |
1-Acetyl-β-carboline (32-64 μg/mL) exhibits synergistic antimicrobial activity against MRSA strains when used in combination with β-lactam antibiotics[2].
1-Acetyl-β-carboline shows antibacterial activity against MRSA strains tested with MICs ranging from 128 to 256 ug/mL[2].
1-Acetyl-β-carboline (12.5-50 μM; 72 h) increases the melanin content and the tyrosinase activity in B16F10 melanoma cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16F10 melanoma cells
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Concentration:12.5, 25, 50 μM
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Incubation Time:24 h
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Result:Significantly increased the expression levels of melanogenic enzymes (tyrosinase, TRP-1, TRP-2) and MITF at 50 μM.
Reduced ERK phosphorylation by 20.79% at 12.5 μM and 25.63% at 25 μM.
Chemical Information
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CAS No. 50892-83-6
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Appearance Solid
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Molecular Weight 210.23
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Formula C13H10N2O
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Color Light yellow to yellow
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SMILES
CC(C1=NC=CC2=C1NC3=CC=CC=C32)=O
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Structure Classification
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Initial Source
Nonomuraea endophytica
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (237.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7567 mL | 23.7835 mL | 47.5670 mL | 118.9174 mL |
| 5 mM | 0.9513 mL | 4.7567 mL | 9.5134 mL | 23.7835 mL | |
| 10 mM | 0.4757 mL | 2.3783 mL | 4.7567 mL | 11.8917 mL | |
| 15 mM | 0.3171 mL | 1.5856 mL | 3.1711 mL | 7.9278 mL | |
| 20 mM | 0.2378 mL | 1.1892 mL | 2.3783 mL | 5.9459 mL | |
| 25 mM | 0.1903 mL | 0.9513 mL | 1.9027 mL | 4.7567 mL | |
| 30 mM | 0.1586 mL | 0.7928 mL | 1.5856 mL | 3.9639 mL | |
| 40 mM | 0.1189 mL | 0.5946 mL | 1.1892 mL | 2.9729 mL | |
| 50 mM | 0.0951 mL | 0.4757 mL | 0.9513 mL | 2.3783 mL | |
| 60 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9820 mL | |
| 80 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4865 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4757 mL | 1.1892 mL |
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