1. GPCR/G Protein
  2. Adenosine Receptor
  3. A2A receptor antagonist 1

A2A receptor antagonist 1 (Synonyms: CPI-444 analog)

Cat. No.: HY-102024 Purity: 98.25%
Handling Instructions

A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively.

For research use only. We do not sell to patients.

A2A receptor antagonist 1 Chemical Structure

A2A receptor antagonist 1 Chemical Structure

CAS No. : 443103-97-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 82 In-stock
Estimated Time of Arrival: December 31
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 760 Get quote
100 mg USD 1350 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively[1].

IC50 & Target

Ki: 4 nM (adenosine A2A receptor), 264 nM (A1 receptor)[1]

In Vitro

A2A receptor antagonist 1 (CPI-444 analog) is a potent adenosine A2A receptor antagonist, selective over the A1 receptor and demonstrates its binding activity with Ki values of 4 and 264 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

309.30

Formula

C₁₆H₁₂FN₅O

CAS No.

443103-97-7

SMILES

NC1=NC(C2=CC=CO2)=C3C(N(CC4=C(F)C=CC=C4)N=C3)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (80.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2331 mL 16.1655 mL 32.3311 mL
5 mM 0.6466 mL 3.2331 mL 6.4662 mL
10 mM 0.3233 mL 1.6166 mL 3.2331 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

A2A receptor antagonist 1CPI-444 analogAdenosine ReceptorP1 receptorhypolocomotionmodelParkinsondiseaseInhibitorinhibitorinhibit

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Product Name:
A2A receptor antagonist 1
Cat. No.:
HY-102024
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