2. GPCR/G Protein
  3. Adenosine Receptor
  4. A2A receptor antagonist 1

A2A receptor antagonist 1  (Synonyms: CPI-444 analog)

Cat. No.: HY-102024 Purity: 99.96%
COA Handling Instructions

A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively.

For research use only. We do not sell to patients.

A2A receptor antagonist 1 Chemical Structure

A2A receptor antagonist 1 Chemical Structure

CAS No. : 443103-97-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 82 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 82 In-stock
Solid
1 mg USD 80 In-stock
5 mg USD 120 In-stock
10 mg USD 190 In-stock
50 mg USD 760 In-stock
100 mg USD 1350 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

A2A receptor antagonist 1 Related Antibodies

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View All Adenosine Receptor Isoform Specific Products:

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively[1].
IC50 & Target

Ki: 4 nM (adenosine A2A receptor), 264 nM (A1 receptor)[1]
In Vitro

A2A receptor antagonist 1 (CPI-444 analog) is a potent adenosine A2A receptor antagonist, selective over the A1 receptor and demonstrates its binding activity with Ki values of 4 and 264 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

A2A receptor antagonist 1 Related Antibodies
Molecular Weight

309.30

Appearance

Solid

Formula

C16H12FN5O
CAS No.
SMILES

NC1=NC(C2=CC=CO2)=C3C(N(CC4=C(F)C=CC=C4)N=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (80.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2331 mL 16.1655 mL 32.3311 mL
5 mM 0.6466 mL 3.2331 mL 6.4662 mL
10 mM 0.3233 mL 1.6166 mL 3.2331 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.96%

COA (254 KB) HNMR (276 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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A2A receptor antagonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

A2A receptor antagonist 1443103-97-7CPI-444CPI444CPI 444Adenosine ReceptorP1 receptorhypolocomotionmodelParkinsondiseaseInhibitorinhibitorinhibit

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