1. Immunology/Inflammation
  2. Glucocorticoid Receptor
  3. AZD9567

AZD9567 

Cat. No.: HY-120012 Purity: 99.71%
Handling Instructions

AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

For research use only. We do not sell to patients.

AZD9567 Chemical Structure

AZD9567 Chemical Structure

CAS No. : 1893415-00-3

Size Price Stock
5 mg USD 650 Ask For Quote & Lead Time
10 mg USD 950 Ask For Quote & Lead Time

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Description

AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].

IC50 & Target

IC50: 3.8 nM (Glucocorticoid receptor)[1].

In Vivo

AZD9567 (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW[1].
Dosage: 15 mg/kg/day.
Administration: Oral gavage daily for 8 days.
Result: Inhibited ankle swelling in the rat SCW model.
Clinical Trial
Molecular Weight

494.53

Formula

C27H28F2N4O3

CAS No.
SMILES

CC(F)(F)C(N[[email protected]]([[email protected]](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.21 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0221 mL 10.1106 mL 20.2212 mL
5 mM 0.4044 mL 2.0221 mL 4.0442 mL
10 mM 0.2022 mL 1.0111 mL 2.0221 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.06 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
AZD9567
Cat. No.:
HY-120012
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