1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. AZD9567

AZD9567 

Cat. No.: HY-120012 Purity: >99.0%
Handling Instructions

AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation.

For research use only. We do not sell to patients.

AZD9567 Chemical Structure

AZD9567 Chemical Structure

CAS No. : 1893415-00-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].

IC50 & Target

IC50: 3.8 nM (Glucocorticoid receptor)[1].

In Vivo

AZD9567 (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation[1].

Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW[1].
Dosage: 15 mg/kg/day.
Administration: Oral gavage daily for 8 days.
Result: Inhibited ankle swelling in the rat SCW model.
Clinical Trial
Molecular Weight

494.53

Formula

C₂₇H₂₈F₂N₄O₃

CAS No.

1893415-00-3

SMILES

CC(F)(F)C(N[[email protected]]([[email protected]](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

References
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Product Name:
AZD9567
Cat. No.:
HY-120012
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