1. Stem Cell/Wnt
  2. Wnt

Adavivint (Synonyms: SM04690)

Cat. No.: HY-109049 Purity: >98.0%
Handling Instructions

Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.

For research use only. We do not sell to patients.

Adavivint Chemical Structure

Adavivint Chemical Structure

CAS No. : 1467093-03-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 500 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.

IC50 & Target

EC50: 19.5 nM (Wnt, SW480 cell)[1]

In Vitro

Adavivint (SM04690) is a potent and selective inhibitor of Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells, and shows no effect on SV40 luciferase reporter. Adavivint enhances aggregation of human mesenchymal stem cells (hMSCs) with an EC50 of 10 nM. Adavivint (30 nM) protects chondrocytes from catabolic breakdown in vitro[1].

In Vivo

Adavivint (0.3 μg) enhances cartilage repair and protection in the rat acute cruciate ligament tear and partial medial meniscectomy osteoarthritis (ACLT + pMMx OA) model[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (49.45 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9780 mL 9.8902 mL 19.7804 mL
5 mM 0.3956 mL 1.9780 mL 3.9561 mL
10 mM 0.1978 mL 0.9890 mL 1.9780 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

505.55

Formula

C₂₉H₂₄FN₇O

CAS No.

1467093-03-3

SMILES

CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN=C1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Adavivint
Cat. No.:
HY-109049
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Adavivint

Cat. No.: HY-109049