17 Results for "

Angiotensin 1-7

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "Angiotensin 1-7" in MCE Product Catalog:

17
Talfirastide
Talfirastide
0 Images
17 Cited Publications
Cat. No.: HY-12403
CAS No.: 51833-78-4
Purity:  99.75%
Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7)
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
17
Talfirastide acetate
Talfirastide acetate
0 Images
17 Cited Publications
Cat. No.: HY-12403A
CAS No.: 2855063-75-9
Purity:  99.87%
Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .
15
AVE 0991
AVE 0991
0 Images
15 Cited Publications
Cat. No.: HY-15778
CAS No.: 304462-19-9
Purity:  98.88%
Target:  

Angiotensin Receptor

Research Areas:  

Cardiovascular Disease Endocrinology

AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM .
2
Plantainoside D
Plantainoside D
0 Images
2 Cited Publications
Cat. No.: HY-N5063
CAS No.: 147331-98-4
Category:  

Cardiovascular Disease Simple Phenylpropanols Scrophulariaceae Phenols Polyphenols Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields

Target:  

Angiotensin-converting Enzyme (ACE) IKK Calcium Channel PKC Reactive Oxygen Species (ROS) NF-κB Apoptosis Sirtuin NOD-like Receptor (NLR)

Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension .
1
(D-Pro7)-Angiotensin I/II (1-7)
(D-Pro7)-Angiotensin I/II (1-7)
0 Images
1 Cited Publications
Cat. No.: HY-P1656
CAS No.: 586962-44-9
Target:  

Angiotensin Receptor Mas-related G-protein-coupled Receptor (MRGPR)

Research Areas:  

Cardiovascular Disease

(D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a Ki of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension .
BKIDC-1553
BKIDC-1553
0 Images
Cat. No.: HY-163438
CAS No.: 1951431-34-7
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease Cancer

BKIDC-1553 is an orally active antiglycolytic agent and a bumped kinase inhibitor derived compound with a predicted ~17 h half-life in human. BKIDC-1553 inhibits CYP2C8 and Angiotensin Converting Enzyme and can be used for cancer research .
Zofenoprilat
Zofenoprilat
0 Images
Cat. No.: HY-133829
CAS No.: 75176-37-3
Target:  

Angiotensin-converting Enzyme (ACE) NO Synthase Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease

Zofenoprilat is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.7 nM. Zofenoprilat exerts cardioprotective and renoprotective effects by inhibiting angiotensin II expression and lowering blood pressure. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression. Zofenoprilat decreases TNFα-induced ROS production and protects vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules and possesses antioxidant activity. Zofenoprilat can be used in studies related to hypertension and congestive heart failure .
Talfirastide (Standard)
Talfirastide (Standard)
0 Images
Cat. No.: HY-12403R
CAS No.: 51833-78-4
Synonyms: TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite Reference Standards

Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
L-162537
L-162537
0 Images
Cat. No.: HY-108120
CAS No.: 167027-99-8
Target:  

Angiotensin Receptor

Research Areas:  

Cardiovascular Disease

L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension .
MIPS3526
MIPS3526
0 Images
Cat. No.: HY-179277
Target:  

Adenosine Receptor

Research Areas:  

Cardiovascular Disease

MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver .
5-Valine-angiotensin I
5-Valine-angiotensin I
0 Images
Cat. No.: HY-P3545
CAS No.: 484-43-5
Target:  

Angiotensin Receptor

Research Areas:  

Cardiovascular Disease

5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone .
RB-105
RB-105
0 Images
Cat. No.: HY-19200
CAS No.: 155895-89-9
Target:  

Neprilysin Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease

RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension .
SARS-CoV-2-IN-109
SARS-CoV-2-IN-109
0 Images
Cat. No.: HY-170767
Target:  

SARS-CoV

Research Areas:  

Infection

SARS-CoV-2-IN-109 (compound 50) is an inhibitor targeting SARS-CoV with in vivo anti-infection activity. SARS-CoV-2-IN-109 targets the interaction between the SARS-CoV-2 Spike receptor-binding domain (RBD) and the human receptor angiotensin-converting enzyme 2 (ACE2) (EC50=26.5 μM), blocking the entry of SARS-CoV-2 into VeroE6 cells (EC50=17.0 μM). The CC50 of SARS-CoV-2-IN-109 for VeroE6 cells is >100 μM .
A-779 TFA
A-779 TFA
0 Images
Cat. No.: HY-P0216A
Target:  

Angiotensin Receptor

Research Areas:  

Cardiovascular Disease

A-779 TFA is a selective angiotensin-(1-7) (Ang-(1-7)) antagonist. A-779 TFA blocks Arachidonic acid release, bradykinin potentiation effects and hypotensive action. A-779 TFA exerts diuretic effects in non-pregnant rats, antidiuretic effects in late-pregnant rats, and also inhibits feed intake and water consumption in late-pregnant rats. A-779 TFA attenuates the regulatory effects of prostacyclin, nitric oxide and thromboxane A2 associated with angiotensin-(1-7). A-779 TFA can be used in studies related to hypertension .
PNA5
PNA5
0 Images
Cat. No.: HY-167153
CAS No.: 2186644-51-7
Target:  

Interleukin Related Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases Iba-1 expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases .
ACE2 Antibody (YA647)
ACE2 Antibody (YA647)
0 Images
Cat. No.: HY-P80003
Synonyms: ACE-2; ACE 2; Angiotensin converting enzyme 2; ACE related carboxypeptidase; ACEH; Angiotensin converting enzyme homolog; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; DKFZP434A014; EC 3.4.17; Angiotensin-converting enzyme 2 precursor; ACE2_HUMAN; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15; Processed Angiotensin-converting enzyme 2.

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, IF-Tissue

Reactivity:  

Human, Mouse, Rat, Hamster

LVV-hemorphin-7
LVV-hemorphin-7
0 Images
Cat. No.: HY-P11643
CAS No.: 75808-66-1
Target:  

Angiotensin Receptor Aminopeptidase DNA/RNA Synthesis

Research Areas:  

Neurological Disease

LVV-hemorphin-7 is an Angiotensin IV receptor ligand and IRAP inhibitor (IC50s: 17.6 nM for sheep adrenal IRAP; 5.0 nM for sheep cerebellum IRAP). LVV-hemorphin-7 inhibits the catalytic activity of IRAP. LVV-hemorphin-7 stimulates DNA synthesis. LVV-hemorphin-7 elicits a number of physiological effects, including cellular proliferation and memory enhancement .
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