75176-37-3
Chemical Structure
Zofenoprilat
- CAS No.: 75176-37-3
- Formula:C15H19NO3S2
- Molecular Weight:325.45
IUPAC Name: (2S,4S)-1-((S)-3-mercapto-2-methylpropanoyl)-4-(phenylthio)pyrrolidine-2-carboxylic acid
InChIKey: UQWLOWFDKAFKAP-WXHSDQCUSA-N
SMILES: SC[C@@H](C)C(N1[C@@H](C[C@@H](C1)SC2=CC=CC=C2)C(O)=O)=O
Biological Activity: Zofenoprilat is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.7 nM. Zofenoprilat exerts cardioprotective and renoprotective effects by inhibiting angiotensin II expression and lowering blood pressure. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression. Zofenoprilat decreases TNFα-induced ROS production and protects vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules and possesses antioxidant activity. Zofenoprilat can be used in studies related to hypertension and congestive heart failure[1][2].
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Zofenoprilat | Zofenoprilat is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.7 nM. Zofenoprilat exerts cardioprotective and renoprotective effects by inhibiting angiotensin II expression and lowering blood pressure. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression. Zofenoprilat decreases TNFα-induced ROS production and protects vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules and possesses antioxidant activity. Zofenoprilat can be used in studies related to hypertension and congestive heart failure. | |||||||||||||||||||||
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- [1]. Ranadive SA, et al. Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors. Pharm Res. 1992;9(11):1480-1486. [Content Brief]
- [2]. Desideri G, et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087. [Content Brief]
Keywords
