2186644-51-7
Chemical Structure
PNA5
- CAS No.: 2186644-51-7
- Formula:C45H71N13O16
- Molecular Weight:1050.12
InChIKey: MREIEXHOTNPVMV-UXMKKAROSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@H](C(N)=O)CO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=O)CC3=CN=CN3)=O)=O
Biological Activity: PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases Iba-1 expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases[1].
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PNA5 | PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases IL-10. PNA5 inhibits ROS generation, decreases Iba-1 expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases. | |||||||||||||||||||||
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