155895-89-9
Chemical Structure
RB-105
- CAS No.: 155895-89-9
- Formula:C14H19NO3S
- Molecular Weight:281.37
IUPAC Name: ((2S,3R)-2-(mercaptomethyl)-3-phenylbutanoyl)-L-alanine
InChIKey: ABBSOQIXYPZCKO-NHCYSSNCSA-N
SMILES: C[C@@H](C(O)=O)NC([C@@H](CS)[C@H](C1=CC=CC=C1)C)=O
Biological Activity: RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
RB-105 | RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
