586962-44-9
Chemical Structure
(D-Pro7)-Angiotensin I/II (1-7)
- CAS No.: 586962-44-9
- Formula:C41H62N12O11
- Molecular Weight:899.00
InChIKey: PVHLMTREZMEJCG-SMAUMWCNSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](CCC3)C(O)=O)=O)=O)=O
Biological Activity: (D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a Ki of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(D-Pro7)-Angiotensin I/II (1-7) | 99.95% | (D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a Ki of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension. | ||||||||||||||||||||
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- [1]. Padda RS, et al. Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? J Diabetes Metab. 2015 Oct 14;6(10):10.4172/2155-6156.1000615. [Content Brief]
- [2]. Özen N, et al. Effect of swimming exercise on angiotensin-(1–7)-mediated aortic dilation responses in the nitric oxide synthase inhibition-induced hypertensive rats[J]. Cukurova Medical Journal, 2025, 50(4): 1092-1102.
Keywords
