1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. Bay 59-3074

Bay 59-3074 

Cat. No.: HY-100488 Purity: 98.85%
Handling Instructions

Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors, respectively. Bay 59-3074 has analgesic properties.

For research use only. We do not sell to patients.

Bay 59-3074 Chemical Structure

Bay 59-3074 Chemical Structure

CAS No. : 406205-74-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors, respectively. Bay 59-3074 has analgesic properties[1].

IC50 & Target[1]

CB1

48.3 nM (Ki)

CB2

45.5 nM (Ki)

In Vivo

BAY 59-3074 (0.3-3 mg/kg; oral administration; daily; for 2 weeks; male Wistar rats) treatment improves antihyperalgesic and antiallodynic effects against thermal or mechanical stimuli in rat models of chronic neuropathic and inflammatory pain.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (160-250 g)[1]
Dosage: 0.3 mg/kg, 1 mg/kg, and 3 mg/kg
Administration: Oral administration; daily; for 2 weeks.
Result: Antiallodynic efficacy in the spared nerve injury model was maintained after 2 weeks of daily administration. Tolerance developed rapidly (within 5 days) for cannabinoid-related side effects. Antihyperalgesic and antiallodynic efficacy was maintained/increased.
Molecular Weight

453.36

Formula

C₁₈H₁₃F₆NO₄S

CAS No.
SMILES

O=S(CCCC(F)(F)F)(OC1=CC=CC(OC2=CC=CC(C(F)(F)F)=C2C#N)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (75.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2058 mL 11.0288 mL 22.0575 mL
5 mM 0.4412 mL 2.2058 mL 4.4115 mL
10 mM 0.2206 mL 1.1029 mL 2.2058 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Bay 59-3074Cannabinoid ReceptorInhibitorinhibitorinhibit

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Product Name:
Bay 59-3074
Cat. No.:
HY-100488
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