1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. Bay 59-3074

Bay 59-3074 

Cat. No.: HY-100488 Purity: 98.85%
Handling Instructions

Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors, respectively. Bay 59-3074 has analgesic properties.

For research use only. We do not sell to patients.

Bay 59-3074 Chemical Structure

Bay 59-3074 Chemical Structure

CAS No. : 406205-74-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Estimated Time of Arrival: December 31
100 mg USD 804 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors, respectively. Bay 59-3074 has analgesic properties[1].

IC50 & Target[1]

CB1

48.3 nM (Ki)

CB2

45.5 nM (Ki)

In Vivo

BAY 59-3074 (0.3-3 mg/kg; oral administration; daily; for 2 weeks; male Wistar rats) treatment improves antihyperalgesic and antiallodynic effects against thermal or mechanical stimuli in rat models of chronic neuropathic and inflammatory pain.

Animal Model: Male Wistar rats (160-250 g)[1]
Dosage: 0.3 mg/kg, 1 mg/kg, and 3 mg/kg
Administration: Oral administration; daily; for 2 weeks.
Result: Antiallodynic efficacy in the spared nerve injury model was maintained after 2 weeks of daily administration. Tolerance developed rapidly (within 5 days) for cannabinoid-related side effects. Antihyperalgesic and antiallodynic efficacy was maintained/increased.
Molecular Weight

453.36

Formula

C₁₈H₁₃F₆NO₄S

CAS No.

406205-74-1

SMILES

O=S(CCCC(F)(F)F)(OC1=CC=CC(OC2=CC=CC(C(F)(F)F)=C2C#N)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (75.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2058 mL 11.0288 mL 22.0575 mL
5 mM 0.4412 mL 2.2058 mL 4.4115 mL
10 mM 0.2206 mL 1.1029 mL 2.2058 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Bay 59-3074
Cat. No.:
HY-100488
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