Infection

Acetaminophen glucuronide (sodium salt) (Standard) is the analytical standard of Acetaminophen glucuronide (sodium salt). This product is intended for research and analytical applications. Acetaminophen glucuronide is a safe and effective antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver and kidney .

Flumorph (Standard) is the analytical standard of Flumorph. This product is intended for research and analytical applications. 0

Tioxacin is an orally active bactericide agent. Tioxacin combined with aliphatic amines has activities against G(+) and G (-) bacteria, including Escherichia coli resistant to Nalidixic acid (HY-B0398) and Pseudomonas aeruginosa.

Aminobutane bisphosphonate is a Trypanosoma cruzi farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC₅₀ of 30.77 μM against Trypanosoma cruzi. Aminobutane bisphosphonate inhibits proliferation of intracellular amastigote Trypanosoma cruzi and lacks activity against non-infective epimastigote forms. Aminobutane bisphosphonate reduces osteoclastic bone resorption, osteoid surface extent, and osteoclast number per mm of bone surface. Aminobutane bisphosphonate can be used for the research of american trypanosomiasis (chagas' disease) and immobilization-related bone loss.

GC376 (sodium) (Standard) is the analytical standard of GC376 (sodium) (HY-100721). This product is intended for research and analytical applications. GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively.

ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC₅₀ of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection.

Antimicrobial agent-51 is an antifungal agent that increases ROS levels, reduces mitochondrial membrane potential, alters hyphal morphology, and impairs cell membrane integrity. Antimicrobial agent-51 inhibits succinate dehydrogenase (SDH) with an IC₅₀ of 0.76 μg/mL against Colletotrichum gloeosporioides. Antimicrobial agent-51 exhibits control efficacy against Alternaria solani on tomato fruits and shows low toxicity to plant and mammalian cells. Antimicrobial agent-51 can be used for the research of plant fungal diseases.

Uredofos is a broad-spectrum anthelmintic. Uredofos has anticestodal activity.

Neosolaniol (Standard) is the analytical standard of Neosolaniol (HY-N6799). This product is intended for research and analytical applications. Neosolaniol is an orally active type A trichothecene mycotoxin, and it is a metabolite of T-2 Toxin (HY-N6792) in human cancer cells and renal epithelial cells. Neosolaniol targets Bax, Bcl-2, caspase 3, caspase 8, and cytochrome c, thereby inducing apoptosis, emesis and anorexia. Neosolaniol reduces intracellular ATP levels, elevates ROS levels, decreases mitochondrial membrane potential, induces mitochondrial damage, and exerts toxicity on Leydig cells. Neosolaniol downregulates the expression of intestinal tight junction proteins in broilers and increases the load of Salmonella enteritidis in the cecum of broilers. Neosolaniol can be used in research related to anorexia, lymphoma, Fusarium melonis rot, and Salmonella infection.

(E)-Antibacterial agent 210 is the isomer of Antibacterial agent 210 (HY-163508). Antibacterial agent 210 is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR.

Golgicide A-1 (Standard) is the analytical standard of Golgicide A-1 (HY-100540C). This product is intended for research and analytical applications. Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction.

Liranaftate (Standard) is the analytical standard of Liranaftate. This product is intended for research and analytical applications. Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation.

Roselipin 2B inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.

(-)-Bornyl acetate (Standard) is the analytical standard of (-)-Bornyl acetate. This product is intended for research and analytical applications. (-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity.

Tavaborole (Standard) is the analytical standard of Tavaborole. This product is intended for research and analytical applications. Tavaborole (AN-2690) is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis.

Matairesinol-d₆ is the deuterium labeled Matairesinol. Matairesinol confers anti-allergic effects in an allergic dermatitis mouse model. DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application.

cis-ICeD-2 is the cis isomer of ICeD-2 (HY-151871). ICeD-2 is a cell death inducer that induces cell death in HIV-1-infected cells. ICeD-2-mediated killing of HIV-1-infected cells is dependent on HIV-1 protease activity. ICeD-2 effectively blocks the hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 demonstrates strong stability against DPP9 in PBMCs..

MMV1581361 is a PfATP4 inhibitor and an orally active, transmission-blocking agent with nanomolar activity against Plasmodium falciparum blood-stage isolates. MMV1581361 disrupts sodium ion (Na⁺) homeostasis in Plasmodium falciparum. MMV1581361 inhibits male gamete exflagellation, reduces oocyst intensity, and blocks transmission of Plasmodium falciparum. MMV1581361 demonstrates efficacy in the humanized Plasmodium falciparum NOD scid IL2Rγ^null mouse model. MMV1581361 can be used for the research of malaria.

Antiviral agent 66 (Compound 60) is the inhibitor for Filovirus, that inhibits pseudotyped virus of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston and Tai Forest with EC₅₀s of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21 and 0.11 μM, respectively.

BL-8030 is an anti-HCV agent. BL-8030 can be used for the research of infection.