36519-25-2
Chemical Structure
Neosolaniol
- CAS No.: 36519-25-2
- Formula:C19H26O8
- Molecular Weight:382.40
IUPAC Name: ((2'R,3'R,4'S,5a'R,7'S,9a'R)-4'-acetoxy-3',7'-dihydroxy-5',8'-dimethyl-2',3',4',5',7',9a'-hexahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-5a'(6'H)-yl)methyl acetate
InChIKey: TVZHDVCTOCZDNE-WZSGEPEASA-N
SMILES: CC12C3(CO3)[C@@](O[C@@]4([H])[C@@]2(C[C@H](O)C(C)=C4)COC(C)=O)([H])[C@H](O)[C@H]1OC(C)=O
Biological Activity: Neosolaniol is an orally active type A trichothecene mycotoxin, and it is a metabolite of T-2 Toxin (HY-N6792) in human cancer cells and renal epithelial cells. Neosolaniol targets Bax, Bcl-2, caspase 3, caspase 8, and cytochrome c, thereby inducing apoptosis, emesis and anorexia. Neosolaniol reduces intracellular ATP levels, elevates ROS levels, decreases mitochondrial membrane potential, induces mitochondrial damage, and exerts toxicity on Leydig cells. Neosolaniol downregulates the expression of intestinal tight junction proteins in broilers and increases the load of Salmonella enteritidis in the cecum of broilers. Neosolaniol can be used in research related to anorexia, lymphoma, Fusarium melonis rot, and Salmonella infection[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Neosolaniol | 99.72% | Neosolaniol is an orally active type A trichothecene mycotoxin, and it is a metabolite of T-2 Toxin (HY-N6792) in human cancer cells and renal epithelial cells. Neosolaniol targets Bax, Bcl-2, caspase 3, caspase 8, and cytochrome c, thereby inducing apoptosis, emesis and anorexia. Neosolaniol reduces intracellular ATP levels, elevates ROS levels, decreases mitochondrial membrane potential, induces mitochondrial damage, and exerts toxicity on Leydig cells. Neosolaniol downregulates the expression of intestinal tight junction proteins in broilers and increases the load of Salmonella enteritidis in the cecum of broilers. Neosolaniol can be used in research related to anorexia, lymphoma, Fusarium melonis rot, and Salmonella infection. | ||||||||||||||||||||
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Neosolaniol (Standard) | ≥98% | Neosolaniol (Standard) is the analytical standard of Neosolaniol (HY-N6799). This product is intended for research and analytical applications. Neosolaniol is an orally active type A trichothecene mycotoxin, and it is a metabolite of T-2 Toxin (HY-N6792) in human cancer cells and renal epithelial cells. Neosolaniol targets Bax, Bcl-2, caspase 3, caspase 8, and cytochrome c, thereby inducing apoptosis, emesis and anorexia. Neosolaniol reduces intracellular ATP levels, elevates ROS levels, decreases mitochondrial membrane potential, induces mitochondrial damage, and exerts toxicity on Leydig cells. Neosolaniol downregulates the expression of intestinal tight junction proteins in broilers and increases the load of Salmonella enteritidis in the cecum of broilers. Neosolaniol can be used in research related to anorexia, lymphoma, Fusarium melonis rot, and Salmonella infection. | ||||||||||||||||||||
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- [1]. Xu J, et al. Potential Role of Individual and Combined Effects of T-2 Toxin, HT-2 Toxin and Neosolaniol on the Apoptosis of Porcine Leydig Cells. Toxins (Basel). 2022;14(2):145. Published 2022 Feb 16. [Content Brief]
- [2]. Wu Q, et al. The trichothecene neosolaniol stimulates an emetic response through neuropeptide Y2 and serotonin 3 receptors in mink. Toxicology. 2021;452:152718. [Content Brief]
- [3]. Zhang J, et al. Anorectic responses to T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol correspond to plasma elevations of neurotransmitters 5-hydroxytryptamine and substance P. Ecotoxicol Environ Saf. 2018;161:451-458. [Content Brief]
- [4]. Janse van Rensburg DF, et al. Short-term effects of two fusarium toxins, diacetoxyscirpenol and neosolaniol monoacetate, in male Wistar rats. Food Chem Toxicol. 1987;25(10):767-771. [Content Brief]
- [5]. Zhang J, et al. Comparison of Anorectic Potencies of Type A Trichothecenes T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol. Toxins (Basel). 2018;10(5):179. Published 2018 Apr 29. [Content Brief]
- [6]. Weidner M, et al. Identification and apoptotic potential of T-2 toxin metabolites in human cells. J Agric Food Chem. 2012;60(22):5676-5684. [Content Brief]
- [7]. Anderson DW, et al. Structure-activity studies of trichothecenes: cytotoxicity of analogues and reaction products derived from T-2 toxin and neosolaniol. J Med Chem. 1989;32(3):555-562. [Content Brief]
- [8]. Königs M, et al. Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology. 2009;258(2-3):106-115. [Content Brief]
- [9]. Xue H, et al. Acetylsalicylic acid treatment reduce Fusarium rot development and neosolaniol accumulation in muskmelon fruit. Food Chem. 2019;289:278-284. [Content Brief]
- [10]. Liu JD, et al. Short-term exposure to fumonisins and deoxynivalenol, on broiler growth performance and cecal Salmonella load during experimental Salmonella Enteritidis infection. Poult Sci. 2023;102(6):102677. [Content Brief]
Keywords
