Infection

PEX5-PEX14 PPI-IN-4 is a potent PEX14-PEX5 PPI inhibitor, with EC₅₀ values of 7.78 μM, 27.5 μM and 9.31 μM against the protein-protein interactions of TbPEX14-PEX5, TcPEX14-PEX5 and HsPEX14-PEX5, respectively. PEX5-PEX14 PPI-IN-4 exhibits trypanocidal activity against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. PEX5-PEX14 PPI-IN-4 shows cytotoxic activity against mammalian cells. PEX5-PEX14 PPI-IN-4 can be used in the research of human African trypanosomiasis and Chagas disease.

Nifuratel (Standard) is the analytical standard of Nifuratel. This product is intended for research and analytical applications. Nifuratel (NF 113, SAP 113) is a broad-spectrum antibiotic with activity against bacteria, fungi and trichomonas.

Quassin (Standard) is the analytical standard of Quassin. This product is intended for research and analytical applications. Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC₅₀ of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity.

Halofantrine hydrochloride (Standard) is the analytical standard of Halofantrine hydrochloride. This product is intended for research and analytical applications. Halofantrine hydrochloride (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent. Halofantrine hydrochloride inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine hydrochloride exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine hydrochloride can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.

Thiosultap monosodium (Monosultap) is a broad-spectrum insecticide and a competitive inhibitor of acetylcholine. Thiosultap monosodium exerts contact and stomach poisoning effects through systemic conduction in field pests. Thiosultap monosodium has teratogenic effects, induces notochord malformations in zebrafish embryos, and causes apoptosis and abnormally elevated cell proliferation in partial notochord tissues of zebrafish. Thiosultap monosodium is applicable to the research of controlling rice stem borers.

Antiparasitic agent-37 (Compound 4717) is an orally active antiparasitic agent. Antiparasitic agent-37 exhibits activity against S. mansoni in mice. Antiparasitic agent-37 has an oral LD₅₀ of 0.4 g/kg in mice after a single dose. Antiparasitic agent-37 can be used for the research of infectious diseases.

LY 121019 is a semi-synthetic antifungal antibiotic with strong anticandida activity with MIC₅₀ value of 0.625 μg/mL.

Lawsone methyl ether (Standard) (2-​Methoxy-​1,​4-​naphthoquinone (Standard)) is the analytical standard of Lawsone methyl ether (HY-N7116). This product is intended for research and analytical applications. Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.

Dimethoxane is an antibacterial agent and an orally active oncogen. Dimethoxane exerts slow bactericidal action against various bacteria, rapid bacteriostatic action that halts bacterial growth, and does not induce bacterial lysis. Dimethoxane induces multiple tumor formation in rats. Dimethoxane functions as a low-toxicity preservative in cosmetic formulations and controls spoilage microorganisms in aqueous systems, emulsions, and suspensions.

Antimicrobial agent-46 is a inhibitor of Salmonella typhimurium serine acetyltransferase (StSAT) with an IC₅₀ of 48.6 μM. Antimicrobial agent-46 inhibits bacterial growth in minimal medium lacking cysteine (LB 20%). Antimicrobial agent-46 exerts its effect by targeting the cysteine biosynthesis pathway, which is crucial for bacterial persistence and adaptability. Antimicrobial agent-46 exhibits antibacterial activity against the Gram-negative bacterium Escherichia coli. Antimicrobial agent-46 can be used in infection-related research .

Epicorazine A has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine A also has effect on Candida albicans with a MIC of 25 μg/mL.

Ovalichromene B is a flavonone and phytochemical with an IC₅₀ of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre.Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production.Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition.Ovalichromene B can be used for the research of neurodegenerative diseases.Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections.

Hydrocortisone phosphate sodium (Standard) is the analytical standard of Hydrocortisone phosphate sodium (HY-105656). This product is intended for research and analytical applications. Hydrocortisone phosphate sodium is a soft steroid with low anti-inflammatory properties and a short duration of action. Hydrocortisone phosphate sodium can be used for the research for several ocular conditions and gastric ulcers.

Carbocisteine (Standard) is the analytical standard of Carbocisteine. This product is intended for research and analytical applications. Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD).

Crocacin A has anti-yeast and filamentous fungal activity. Crocacin A can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin A can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.

Permetin A is a peptide antibiotic. Permetin A has anti-Gram-negative bacteria, Gram-positive bacteria and anaerobic bacteria activity.

Solithromycin (Standard) is the analytical standard of Solithromycin. This product is intended for research and analytical applications. Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC₅₀s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis.

Ampelopsin A is a antifungal agent and can be isolated from the Vitis vinifera canes. Ampelopsin A shows neuroprotective effects.

LRH-0003 is an inhibitor of the Macrodomain 1 (Mac1) of nonstructural protein 3 (NSP3) from SARS-CoV-2, with an IC₅₀ value of 1.7 μM. LRH-0003 can be used for the research antiviral infection targeting SARS-CoV-2.

Sambutoxin is a mycotoxin. Sambutoxin can be isolated from wheat culture of Fusarium sambucinum.