2. Others Metabolic Enzyme/Protease Apoptosis
  3. Insecticide Angiotensin-converting Enzyme (ACE) Apoptosis
  4. Thiosultap monosodium

Thiosultap monosodium (Monosultap) is a broad-spectrum insecticide and a competitive inhibitor of acetylcholine. Thiosultap monosodium exerts contact and stomach poisoning effects through systemic conduction in field pests. Thiosultap monosodium has teratogenic effects, induces notochord malformations in zebrafish embryos, and causes apoptosis and abnormally elevated cell proliferation in partial notochord tissues of zebrafish. Thiosultap monosodium is applicable to the research of controlling rice stem borers.

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Thiosultap monosodium

Thiosultap monosodium Chemical Structure

CAS No. : 29547-00-0

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Description

Thiosultap monosodium (Monosultap) is a broad-spectrum insecticide and a competitive inhibitor of acetylcholine. Thiosultap monosodium exerts contact and stomach poisoning effects through systemic conduction in field pests. Thiosultap monosodium has teratogenic effects, induces notochord malformations in zebrafish embryos, and causes apoptosis and abnormally elevated cell proliferation in partial notochord tissues of zebrafish. Thiosultap monosodium is applicable to the research of controlling rice stem borers[1].

In Vivo

Thiosultap monosodium (0.25-0.75 mg/L) induces concentration-dependent developmental toxicity and notochord toxicity in zebrafish embryos, including body length shortening, inhibited hatching rate, increased heart rate, impaired motor ability, damaged notochord structure, upregulated expression of notochord-related genes, oxidative stress, as well as elevated levels of apoptosis and proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

333.40

Formula

C5H12NNaO6S4
CAS No.
Appearance

Solid

SMILES

O=S(SCC(CSS(=O)(O)=O)N(C)C)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (299.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9994 mL 14.9970 mL 29.9940 mL
5 mM 0.5999 mL 2.9994 mL 5.9988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9994 mL 14.9970 mL 29.9940 mL 74.9850 mL
5 mM 0.5999 mL 2.9994 mL 5.9988 mL 14.9970 mL
10 mM 0.2999 mL 1.4997 mL 2.9994 mL 7.4985 mL
15 mM 0.2000 mL 0.9998 mL 1.9996 mL 4.9990 mL
20 mM 0.1500 mL 0.7499 mL 1.4997 mL 3.7493 mL
25 mM 0.1200 mL 0.5999 mL 1.1998 mL 2.9994 mL
30 mM 0.1000 mL 0.4999 mL 0.9998 mL 2.4995 mL
40 mM 0.0750 mL 0.3749 mL 0.7499 mL 1.8746 mL
50 mM 0.0600 mL 0.2999 mL 0.5999 mL 1.4997 mL
60 mM 0.0500 mL 0.2500 mL 0.4999 mL 1.2498 mL
80 mM 0.0375 mL 0.1875 mL 0.3749 mL 0.9373 mL
100 mM 0.0300 mL 0.1500 mL 0.2999 mL 0.7499 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Keywords:

Thiosultap monosodium29547-00-0MonosultapInsecticideAngiotensin-converting Enzyme (ACE)Apoptosisnotochord development-related genesacetylcholinezebrafish embryosrice fieldsnotochord deformityapoptosisstem borerscell proliferationnotochord developmentlepidopteran pest larvaeInhibitorinhibitorinhibit

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