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Cat. No.: HY-W705093

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Dimethoxane

Dimethoxane is an antibacterial agent and an orally active oncogen. Dimethoxane exerts slow bactericidal action against various bacteria, rapid bacteriostatic action that halts bacterial growth, and does not induce bacterial lysis. Dimethoxane induces multiple tumor formation in rats. Dimethoxane functions as a low-toxicity preservative in cosmetic formulations and controls spoilage microorganisms in aqueous systems, emulsions, and suspensions.

For research use only. We do not sell to patients.

CAS No.: 828-00-2
Formula: C₈H₁₄O₄
Molecular Weight:174.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dimethoxane Chemical Structure

CAS No.: 828-00-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Dimethoxane exhibits minimum inhibitory concentrations of 500 μg/cm3 against Pseudomonas aeruginosa NCTC 6750, 750 μg/cm³ against Escherichia coli 15TAU NCIB 10430, and 1000 μg/cm³ against Staphylococcus aureus NCTC 6571 in a broth serial dilution assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dimethoxane (1% solution in drinking water; p.o.; continuous; 613 days) induces a 56% tumor incidence (14 tumors in 25 rats) in male Wistar rats, including hepatomas, kidney carcinoma, skin and subcutaneous sarcomas/carcinomas, lymphosarcomas, and leukemia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (young-adult male, 120-180 g)^[2]
Dosage:

1% solution in drinking water; average total dose 237 g
Administration:

oral; continuous; 613 days
Result:

Detected 14 total tumors among 25 treated rats.
Induced 8 hepatomas, 1 papillary transitional cell carcinoma of the kidney, 2 skin and subcutaneous tumors, 2 lymphosarcomas, and 1 myelogenous leukemia.
Caused death in 5 rats, 4 of which had tumors.
Observed hepatomas with numerous small foci, including one undifferentiated tumor over 3 cm in diameter; kidney tumor measuring 5.3 cm; skin epidermoid carcinoma measuring 2 cm; subcutaneous fibrosarcoma measuring 6 cm; mediastinal lymphosarcoma measuring 1.0 × 0.5 cm; and submandibular lymphosarcoma measuring 8 × 6 × 4 cm.

Chemical Information

CAS No. 828-00-2
Molecular Weight 174.20
Formula C₈H₁₄O₄
SMILES

O=C(OC1OC(OC(C)C1)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Woolfson A D. The antibacterial activity of dimethoxane[J]. Journal of Pharmacy and Pharmacology, 1977, 29(Supplement_1): 73P-73P.

[2]. Hoch-Ligeti C, et al. Oncogenic activity of an m-dioxane derivative: 2, 6-Dimethyl-m-dioxan-4-01 acetate (dimethoxane)[J]. Journal of the National Cancer Institute, 1974, 53(3): 791-794.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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