Infection

Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection.

Mutalomycin is a polyether antibiotic. Mutalomycin has anti-Gram-positive bacteria, anti-mycoplasma and anti-coccidial activity.

Minosaminomycin is an antibiotic containing myo-inosamine that can be extracted from Streptomyces No. MA514A1. Minosaminomycin exerts antimicrobial activity against Mycobacterium smegrnatis ATCC 607 and Mycobacterium phlei (MIC= 1.56/6.25 mcg/mL).

Nithiazine is a neonicotinoid insecticide that induces death in adult house flies via ingestion of sugar baits. The resistance level to Nithiazine is low.

Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields.

Piperaquine (phosphate) (Standard) is the analytical standard of Piperaquine (phosphate). This product is intended for research and analytical applications. Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin.

Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC₅₀ of 12 μM. Naphthol AS-BS can be used for the research of infection.

LY456236 (Standard) is the analytical standard of LY456236 (HY-103566). This product is intended for research and analytical applications. LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC₅₀ of 0.145 μM. LY456236 can also inhibit EGFR, with an IC₅₀ of 0.918 μM. LY456236 has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research.

Cephalomycin A shows weak activity against Gram-positive and negative bacteria.

Radulone A is a secondary metabolite, which can be isolated from the wood decomposing fungus Granulobasidium vellereum. Radulone A inhibits spore germination of Phlebiopsis gigantea, Coniophora puteana and Heterobasidion occidentale, with concentrations of 10 µM, 500 µM and 100 µM, respectively.

Ac-CoA Synthase-IN-1 (Standard) is the analytical standard of Ac-CoA Synthase-IN-1 (HY-104032). This product is intended for research and analytical applications. Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC₅₀ of 0.6 μM. Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV).

2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, where it contributes to the mating behavior of males, as well as in D. melanogaster females where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.

Chlorthion is an organic phosphorothionate insecticide. Chlorthion inhibits liver microsomal hydroxylation of testosterone.

Bekanamycin (Standard) is the analytical standard of Bekanamycin. This product is intended for research and analytical applications. Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain.

(R)-GSK-F1 is the R-type isomer of GSK-F1 (HY-100603). GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC₅₀ values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research.

Jietacin A is a nematicide. Jietacin A exhibits nematicidal activity against pine wood nematodes. Jietacin A can be used in studies related to pine wood nematode infection and pine wilt disease.

3,4,5-Trimethoxybenzaldehyde (Standard) is the analytical standard of 3,4,5-Trimethoxybenzaldehyde (HY-W009886). This product is intended for research and analytical applications. 3,4,5-Trimethoxybenzaldehyde is a derivative of benzaldehyde. 3,4,5-Trimethoxybenzaldehyde has antimicrobial activity. 3,4,5-Trimethoxybenzaldehyde is also an important intermediate for the synthesis of various drugs, such as Trimethoprim (HY-B0510).

Fmoc-L-Lys (Boc)-OH-¹³C₆,¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Fmoc-L-Lys (Boc)-OH (HY-79128). Fmoc-L-Lys (Boc)-OH is a lysine derivative.

Cefetamet (Standard) is the analytical standard of Cefetamet (HY-A0111). This product is intended for research and analytical applications. Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC₅₀ for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.

Antiparasitic agent-37 (Compound 4717) is an orally active antiparasitic agent. Antiparasitic agent-37 exhibits activity against S. mansoni in mice. Antiparasitic agent-37 has an oral LD₅₀ of 0.4 g/kg in mice after a single dose. Antiparasitic agent-37 can be used for the research of infectious diseases.