Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
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Potassium Channel Inhibitors
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Potassium Channel Agonists
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Potassium Channel Antagonists
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Potassium Channel Activators
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Potassium Channel Modulators
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Potassium Channel Chemical
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Potassium Channel Controls
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Potassium Channel Related Products (1121)
Related Products (1121)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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VU0494372
0 ImagesCat. No.: HY-179065CAS No.: 882235-30-5VU0494372 is an activator of potassium ion channel KCNQ1. VU0494372 can significantly enhance the cell surface expression and transport efficiency of KCNQ1. VU0494372 does not alter KCNQ1 mRNA levels and protein degradation rate, and has no significant cytotoxicity. VU0494372 can be used for research on cardiovascular conditions.
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Ipazilide fumarate
0 ImagesCat. No.: HY-106330ACAS No.: 115436-74-3Synonyms: Win 54177-4 fumarateIpazilide fumarate (Win 54177-4 fumarate) is an antiarrhythmic agent. Ipazilide fumarate reduces K+- depolarized tone. Ipazilide fumarate prolongs ventricular refractoriness and possesses antiectopic activity.
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Dehydroindapamide
0 ImagesCat. No.: HY-W420344CAS No.: 63968-75-2Dehydroindapamide is the indole form of Indapamide (HY-B0259). Dehydroindapamide standard can be used to quantitatively measure the Indapamide turnover rate by CYP3A4, which was approximately 10-fold higher than that of Indoline (HY-Y0788), and slightly enhanced affinity for CYP3A4.
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Quinidine sulfate
0 ImagesQuinidine sulfate is an orally active antiarrhythmic agent. Quinidine sulfate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine sulfate exerts sustained block and open-channel block effects on IK(f). Quinidine sulfate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine sulfate can be used in studies related to uterine sarcoma and seizures.
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Kv7.2/Kv7.3 activator-2
0 ImagesCat. No.: HY-172887Kv7.2/Kv7.3 activator-2 is a BBB-penetrable Kv7.2/7.3 activator (EC50: 0.25 μM). Kv7.2/Kv7.3 activator-2 has good photostability. Kv7.2/Kv7.3 activator-2 has potently antiepileptic effects in maximal electroshock (MES) and sc-pentylenetetrazol (sc-PTZ)-induced acute mice seizure models.
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P-CAB agent 1
0 ImagesCat. No.: HY-150555CAS No.: 2374139-68-9P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs).
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Landiolol-d8
0 ImagesCat. No.: HY-100607SSynonyms: ONO1101-d8Landiolol-d8 (ONO1101-d8) is the deuterium labeled Landiolol (HY-100607). Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.
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KMUP-4
0 ImagesCat. No.: HY-129210CAS No.: 864873-81-4KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases.
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Vm24-toxin
0 ImagesCat. No.: HY-P5917CAS No.: 1373890-79-9Synonyms: Vaejovis mexicanus peptide 24Vm24-toxin (Vaejovis mexicanus peptide 24), a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation.
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SDZ PCO 400
0 ImagesCat. No.: HY-W747594CAS No.: 121055-10-5SDZ PCO 400 is a potassium channel modulator that relaxes airway smooth muscle and reverses airway obstruction caused by intravenous bronchospasmodics.
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p38α-IN-14
0 ImagesCat. No.: HY-184936p38α-IN-14 is a selective p38α inhibitor with an IC50 of 65 nM. p38α-IN-14 exhibits only weak inhibitory activity against hERG channels, with an IC50 > 30 μM. p38α-IN-14 can be used in the research of chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriasis and inflammatory bowel disease.
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KCNT1-IN-3
0 ImagesCat. No.: HY-179093CAS No.: 2540501-85-5KCNT1-IN-3 (Compound 31) is a KCNT1 inhibitor with an IC50 value of 30 nM against the wild-type human KCNT1. KCNT1-IN-3 can be used in the research of epilepsy.
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Dofetilide (Standard)
0 ImagesSynonyms: UK 68789 (Standard)Dofetilide (Standard) is the analytical standard of Dofetilide. This product is intended for research and analytical applications. Dofetilide (UK 68789), as a class III antiarrhythmic agent, is an orally active, potent and specific IKr blocker. Dofetilide can be used for the research of cardiovascular disease.
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(-)-(S)-Cibenzoline
0 ImagesCat. No.: HY-106577ACAS No.: 103419-18-7Synonyms: Escibenzoline; (-)-(S)-Cifenline; (-)-(S)-Ro 22-7796(-)-(S)-Cibenzoline (Escibenzoline), a S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent.
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ER degrader 10
0 ImagesCat. No.: HY-170377CAS No.: 3035311-43-1ER degrader 10 (Compound 51) is a selective, orally active degrader and antagonist for estrogen receptor (ER) with a DC50 of 0.43 nM and an IC50 of 0.56 nM. ER degrader 10 inhibits the proliferation of ER-positive cells with IC50s of 0-15 nM. ER degrader 10 exhibits a weak inhibitory activity against hERG channel with an IC50 >40 μM. ER degrader 10 is blood-brain barrier penetrable with a brain/plasma ratio (Kp) of 3.05. ER degrader 10 exhibits antitumor efficacy in mice model.
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Uridine 5'-monophosphate disodium salt (Standard)
0 ImagesSynonyms: 5'-Uridylic acid disodium salt (Standard)Uridine 5'-monophosphate (disodium salt) (Standard) is the analytical standard of Uridine 5'-monophosphate (disodium salt). This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
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α-Dendrotoxin
0 ImagesCat. No.: HY-P2707CAS No.: 74504-53-3Synonyms: α-DTXα-Dendrotoxin (α-DTX) is a voltage-gated K+ channel blocker and an acid-sensing ion channel (ASIC) inhibitor. α-Dendrotoxin blocks Kv1.1, Kv1.2, Kv1.6 and D-type (ID) voltage-gated K+ channels, and reversibly inhibits slowly inactivating potassium currents. α-Dendrotoxin induces epilepsy-related behaviors in mice. α-Dendrotoxin can be used in studies related to tonic-clonic seizures.
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Kv3.1 activator-1
0 ImagesCat. No.: HY-184663Kv3.1 activator-1 is a Kv3.1 voltage-gated potassium channel activator. Kv3.1 activator-1 exhibits distinct activating efficacy in both thallium flux assays and automated patch-clamp electrophysiological assays .
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(R)-SKF 38393 hydrochloride
0 ImagesCat. No.: HY-12520BCAS No.: 81702-42-3Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel.
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Quinine sulfate hydrate (Standard)
0 ImagesCat. No.: HY-W010668RCAS No.: 6119-70-6Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
