p38α-IN-14
p38α-IN-14 is a selective p38α inhibitor with an IC50 of 65 nM. p38α-IN-14 exhibits only weak inhibitory activity against hERG channels, with an IC50 > 30 μM. p38α-IN-14 can be used in the research of chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriasis and inflammatory bowel disease.
For research use only. We do not sell to patients.
- Formula: C16H18ClN3OS
- Molecular Weight:335.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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p38α 65 nM (IC50) |
p38α-IN-14 (Compound I-13) potently inhibits purified p38α MAP kinase activity with an IC50 of 65 nM[1].
p38α-IN-14 inhibits purified p38α MAP kinase with 4-fold selectivity over p38β and >461-fold selectivity over p38γ and p38δ[1].
p38α-IN-14 binds directly to purified p38α MAP kinase with a Kd of 84.3 nM, confirming target engagement drives its inhibitory activity[1].
p38α-IN-14 (30 μM) shows weak inhibition of hERG channels, with 26.7% inhibition at 30 μM and an IC50 > 30 μM, indicating low cardiotoxicity risk[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 335.85
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Formula C16H18ClN3OS
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SMILES
CC1=CC=CC(Cl)=C1NC(C2=CN=C(NCC3CCC3)S2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p38α-IN-14 Related Classifications
HY-184936 Related Classifications
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