STING
Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS
Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.
STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.
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STING Inhibitors
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STING Agonists
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STING Antagonists
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STING Activators
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STING Modulators
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STING Degraders
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STING Controls
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STING Ligands
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STING Related Products (254)
Related Products (254)
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Antibodies (13)
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Ulevostinag
0 ImagesCat. No.: HY-139586CAS No.: 2082743-96-0Synonyms: MK-1454Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research.
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STING agonist-18
0 ImagesSTING agonist-18 (compound 1a) is a STING agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate.
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IACS-8803
0 ImagesCat. No.: HY-130115CAS No.: 2095690-70-1IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy.
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STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
0 ImagesCat. No.: HY-148346APurity: 98.30%STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer.
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STING agonist-8
0 ImagesCat. No.: HY-144168CAS No.: 2745723-90-2
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STING agonist-20-Ala-amide-PEG2-C2-NH2
0 ImagesCat. No.: HY-148346CAS No.: 2720500-49-0STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer.
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STING agonist-46
0 ImagesSTING agonist-46 is an orally active STING agonist. STING agonist-46 activates the STING signaling pathway, promoting phosphorylation of TBK1 and IRF3, and secretion of IFN-β and IP-10. STING agonist-46 directly binds to STING and increases its thermal stability. STING agonist-46 demonstrates potent anti-tumor efficacy in B16F10, CT26, and 4T1 mouse models. STING agonist-46 can be used for cancer immunotherapy studies.
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MSA-2-Pt
0 ImagesCat. No.: HY-162133CAS No.: 3028778-96-0MSA-2-Pt, platinum salt-modified MSA-2 (HY-136927), is a STING agonist. MSA-2-Pt inducing cell
death by platinum and activating the STING pathway by MSA-2. MSA-2-Pt direct activates STING pathway, induces phosphorylation of TBK1, IRF3, and NF-κB p65. MSA-2-Pt enhances tumor infiltration of CD4+ and CD8+ T cells, and induces tumor cell death and apoptosis in mouse colon carcinoma and melanoma models.
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ZSA-51
0 ImagesCat. No.: HY-168887CAS No.: 3084542-49-1ZSA-51 is a potent and orally active STING agonist. ZSA-51 shows anticancer activity. ZSA-51 remodeles immune microenvironment both in tumor and lymph node.
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Dazostinag
0 ImagesCat. No.: HY-152861CAS No.: 2553413-86-6Synonyms: TAK-676 free baseDazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs).
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E7766 disodium
0 ImagesCat. No.: HY-111999BCAS No.: 2242636-28-6E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities.
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IACS-8779
0 ImagesCat. No.: HY-130116CAS No.: 2243079-26-5IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy.
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IACS-8779 disodium
0 ImagesCat. No.: HY-130116ACAS No.: 2243079-27-6
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STING agonist-28
0 ImagesCat. No.: HY-152961CAS No.: 2868261-50-9STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains.
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STING agonist-33
0 ImagesCat. No.: HY-153987CAS No.: 2591300-32-0
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STING agonist-24
0 ImagesCat. No.: HY-152957CAS No.: 2408722-91-6STING agonist-24 (CF504) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains.
