3033532-05-4
Chemical Structure
STING agonist-46
- CAS No.: 3033532-05-4
- Formula:C17H21NO5S
- Molecular Weight:351.42
IUPAC Name: 1-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-((isopropylamino)oxy)butane-1,4-dione
InChIKey: YJVAAQFMVCBCFX-UHFFFAOYSA-N
SMILES: O=C(CCC(ONC(C)C)=O)C1=CC2=CC(OC)=C(C=C2S1)OC
Biological Activity: STING agonist-46 is an orally active STING agonist. STING agonist-46 activates the STING signaling pathway, promoting phosphorylation of TBK1 and IRF3, and secretion of IFN-β and IP-10. STING agonist-46 directly binds to STING and increases its thermal stability. STING agonist-46 demonstrates potent anti-tumor efficacy in B16F10, CT26, and 4T1 mouse models. STING agonist-46 can be used for cancer immunotherapy studies[1].
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STING agonist-46 | 98.63% | STING agonist-46 is an orally active STING agonist. STING agonist-46 activates the STING signaling pathway, promoting phosphorylation of TBK1 and IRF3, and secretion of IFN-β and IP-10. STING agonist-46 directly binds to STING and increases its thermal stability. STING agonist-46 demonstrates potent anti-tumor efficacy in B16F10, CT26, and 4T1 mouse models. STING agonist-46 can be used for cancer immunotherapy studies. | ||||||||||||||||||||
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Keywords
