1. Immunology/Inflammation
  2. STING
  3. E7766 disodium

E7766 disodium 

Cat. No.: HY-111999B
Handling Instructions

E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities.

For research use only. We do not sell to patients.

E7766 disodium Chemical Structure

E7766 disodium Chemical Structure

CAS No. : 2242636-28-6

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Description

E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].

In Vitro

E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

792.58

Formula

C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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E7766 disodium
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HY-111999B
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