E7766 diammonium salt

Name: E7766 diammonium salt
Brand: MedChemExpress
SKU: HY-111999A
Rating: 4.5 (1 reviews)

Cat. No.: HY-111999A Purity: 99.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.

For research use only. We do not sell to patients.

E7766 diammonium salt Chemical Structure

CAS No. : 2242635-03-4

Size	Price	Stock	Quantity
1 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2650	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of E7766 diammonium salt:

E7766 disodium Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

E7766 diammonium salt is a macrocycle-bridged STING agonist with a K_d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities^[1].

In Vitro

E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC₅₀ values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

780.66

Formula

C₂₄H₃₂F₂N₁₂O₈P₂S₂

CAS No.

2242635-03-4

Appearance

Solid

Color

White to off-white

SMILES

F[C@@H]1[C@H](O[P@]2(S)=O)[C@@H](CO[P@]3(S)=O)O[C@H]1[N@]4C5=NC=NC(NC/C=C/CNC6=C(N=C[N@]7[C@@H]8O[C@H](CO2)[C@@H](O3)[C@H]8F)C7=NC=N6)=C5N=C4.N.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 45 mg/mL (57.64 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2810 mL	6.4048 mL	12.8097 mL
5 mM	0.2562 mL	1.2810 mL	2.5619 mL
10 mM	0.1281 mL	0.6405 mL	1.2810 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (541 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.2810 mL	6.4048 mL	12.8097 mL	32.0242 mL
	5 mM	0.2562 mL	1.2810 mL	2.5619 mL	6.4048 mL
	10 mM	0.1281 mL	0.6405 mL	1.2810 mL	3.2024 mL
	15 mM	0.0854 mL	0.4270 mL	0.8540 mL	2.1349 mL
	20 mM	0.0640 mL	0.3202 mL	0.6405 mL	1.6012 mL
	25 mM	0.0512 mL	0.2562 mL	0.5124 mL	1.2810 mL
	30 mM	0.0427 mL	0.2135 mL	0.4270 mL	1.0675 mL
	40 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8006 mL
	50 mM	0.0256 mL	0.1281 mL	0.2562 mL	0.6405 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.