E7766 diammonium salt
Based on 5 publication(s) in Google Scholar
E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 2242635-03-4
- Formula: C24H32F2N12O8P2S2
- Molecular Weight:780.66
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) E7766 diammonium salt
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2242635-03-4
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Appearance Solid
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Molecular Weight 780.66
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Formula C24H32F2N12O8P2S2
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Color White to off-white
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SMILES
F[C@@H]1[C@H](O[P@]2(S)=O)[C@@H](CO[P@]3(S)=O)O[C@H]1[N@]4C5=NC=NC(NC/C=C/CNC6=C(N=C[N@]7[C@@H]8O[C@H](CO2)[C@@H](O3)[C@H]8F)C7=NC=N6)=C5N=C4.N.N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Science
2026 May 7;392(6798):eadx1893. PMID: 42096576 -
Science
2025 Oct 9;390(6769):eadl4089. PMID: 41066563 -
Cancer Biol Med
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression. [Abstract]2026 Feb 16;23(1):133-153. PMID: 41700809 -
J Exp Med
2026 May 4;223(5):e20251796. PMID: 41874365 -
Solvent & Solubility
H2O : 45 mg/mL (57.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2810 mL | 6.4048 mL | 12.8097 mL | 32.0242 mL |
| 5 mM | 0.2562 mL | 1.2810 mL | 2.5619 mL | 6.4048 mL | |
| 10 mM | 0.1281 mL | 0.6405 mL | 1.2810 mL | 3.2024 mL | |
| 15 mM | 0.0854 mL | 0.4270 mL | 0.8540 mL | 2.1349 mL | |
| 20 mM | 0.0640 mL | 0.3202 mL | 0.6405 mL | 1.6012 mL | |
| 25 mM | 0.0512 mL | 0.2562 mL | 0.5124 mL | 1.2810 mL | |
| 30 mM | 0.0427 mL | 0.2135 mL | 0.4270 mL | 1.0675 mL | |
| 40 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8006 mL | |
| 50 mM | 0.0256 mL | 0.1281 mL | 0.2562 mL | 0.6405 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
E7766 diammonium salt Related Classifications
HY-111999A Related Classifications
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