3028778-96-0
Chemical Structure
MSA-2-Pt
- CAS No.: 3028778-96-0
- Formula:C28H32N2O10PtS2
- Molecular Weight:815.78
InChIKey: RRVOVNUTYVEWPA-UHFFFAOYSA-L
SMILES: O=C(CCC(C1=CC2=C(C=C(C(OC)=C2)OC)S1)=O)[O-][Pt+2]([NH3])([NH3])[O-]C(CCC(C3=CC4=C(C=C(C(OC)=C4)OC)S3)=O)=O
Biological Activity:
MSA-2-Pt, platinum salt-modified MSA-2 (HY-136927), is a STING agonist. MSA-2-Pt inducing cell
death by platinum and activating the STING pathway by MSA-2. MSA-2-Pt direct activates STING pathway, induces phosphorylation of TBK1, IRF3, and NF-κB p65. MSA-2-Pt enhances tumor infiltration of CD4+ and CD8+ T cells, and induces tumor cell death and apoptosis in mouse colon carcinoma and melanoma models[1].
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MSA-2-Pt | MSA-2-Pt, platinum salt-modified MSA-2 (HY-136927), is a STING agonist. MSA-2-Pt inducing cell death by platinum and activating the STING pathway by MSA-2. MSA-2-Pt direct activates STING pathway, induces phosphorylation of TBK1, IRF3, and NF-κB p65. MSA-2-Pt enhances tumor infiltration of CD4+ and CD8+ T cells, and induces tumor cell death and apoptosis in mouse colon carcinoma and melanoma models. |
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Keywords
