TNFRSF9/4-1BB/CD137 Inhibitor
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Utomilumab
0 ImagesSynonyms: PF 05082566
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Cinrebafusp alfa
0 ImagesSynonyms: PRS 343Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.
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Tecaginlimab
0 ImagesSynonyms: BNT-312; DuoBody-CD40x-4-1BB; GEN1042
