2. Signaling Pathways
  3. GPCR/G Protein
  4. Natriuretic Peptide Receptor (NPR)
  5. Natriuretic Peptide Receptor (NPR) Activator

Natriuretic Peptide Receptor (NPR) Activator

Natriuretic Peptide Receptor (NPR) Activators (6):

Cat. No. Product Name Effect Purity
  • HY-113283
    Homogentisic acid
    		Activator 99.68%
    Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer.
  • HY-122610
    VUT-MK142
    		Activator 99.57%
    VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.
  • HY-P10869
    dCNP
    		Activator
    dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses.
  • HY-120521
    Urodilatin
    		Activator
    Urodilatin is an analogue of ANF-(99-126). Urodilatin is a diuretic-natriuretic regulatory peptide. Urodilatin can be used for research of acute renal failure, congestive heart failure, and bronchial asthma, etc.
  • HY-P3758
    BNP (1-21), Pro (Human)
    		Activator
    BNP (1-21), Pro (Human) is a peptide containg 21 amino acids. B-Type Natriuretic Peptide (BNP), a cardiac natriuretic hormone. BNP together with the highly homologous atrial natriuretic peptide, it forms a dual natriuretic peptide system of the heart. BNP is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life.
  • HY-P3759
    BNP (22-46), Pro (Human)
    		Activator
    BNP (22-46), Pro (Human) is an peptide . BNP (22-46), Pro (Human) can be used for the research of cardiac dysfunction.