SOS1
Ras/Rac guanine nucleotide exchange factor 1
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SOS1 Related Products (82)
Related Products (82)
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SOS1-IN-9
0 ImagesCat. No.: HY-144207CAS No.: 2758900-76-2SOS1-IN-9 is a potent SOS1 inhibitor with an IC50 of 116.5 nM for SOS1-KRAS G12C (WO2022028506A1, compound 302).
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SL43
0 ImagesCat. No.: HY-183365SL43 is an orally active and potent SOS1 inhibitor with a Kd of 0.16 μM. SL43 disrupts SOS1-KRAS interaction, inhibits SOS1-mediated nucleotide exchange on KRAS mutants, and suppresses RAS-MAPK signaling. SL43 exerts antiproliferative activity against KRAS-mutant cancer cells, induces early apoptosis and G1 phase cell cycle arrest, and reduces phosphorylated MEK and ERK levels. SL43 suppresses tumor growth in a colorectal cancer xenograft model.
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SOS1-IN-6
0 ImagesCat. No.: HY-144210CAS No.: 2751718-88-2SOS1-IN-6 (compound 33-P1) is a potent SOS1 inhibitor with IC50s of 14.9 and 73.3 nM for SOS1-G12D and SOS1-G12V, respectively.
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SOS1-IN-21
0 ImagesCat. No.: HY-175326CAS No.: 2767633-04-3SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer.
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PROTAC SOS1 degrader-1
0 ImagesCat. No.: HY-145737CAS No.: 2913185-35-8PROTAC SOS1 degrader-1 is a degrader of SOS1 PROTAC, with a DC50 of 98.4 nM and a Kd value of 44 nM. PROTAC SOS1 degrader-1 induces the formation of a ternary complex with SOS1 and the VCB E3 ubiquitin ligase complex, thereby promoting the ubiquitination and proteasomal degradation of SOS1. PROTAC SOS1 degrader-1 reduces KRAS-GTP levels, inhibits the phosphorylation of ERK in the RAS-RAF-MEK-ERK pathway, and suppresses the proliferation of cancer cells carrying KRAS mutations. PROTAC SOS1 degrader-1 inhibits tumor growth in mouse xenograft models. PROTAC SOS1 degrader-1 can be used for the research of KRAS-driven cancers.
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SAH-SOS1A
0 ImagesCat. No.: HY-P2265CAS No.: 1652561-87-9SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
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SIAIS562055
0 ImagesCat. No.: HY-168637CAS No.: 3062106-15-1SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a Kd of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRASG12C or KRASG12D to SOS1, with the IC50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity.
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SOS1-IN-13
0 ImagesCat. No.: HY-144967CAS No.: 2654741-45-2SOS1-IN-13 is a potent son of sevenless homolog 1 (SOS1) inhibitor with IC50s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 can be used for researching anticancer.
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VHL Ligand intermediate-2
0 ImagesCat. No.: HY-49515CAS No.: 2380273-24-3
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SOS1-IN-28
0 ImagesCat. No.: HY-184586SOS1-IN-28 is an orally active, blood-brain barrier permeable SOS1 inhibitor with an IC50 value of 0.11 μM. SOS1-IN-28 disrupts the SOS1: KRAS protein-protein interaction, with an IC50 of 0.29 μM for the KRAS-RAF interaction. SOS1-IN-28 blocks GTP loading of KRAS, inhibits RAS-MAPK pathway activity, and reduces cancer cell proliferation. SOS1-IN-28 can be used for the research of KRASG12C-mutant lung cancer.
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SOS1 Ligand intermediate-6
0 ImagesCat. No.: HY-163583CAS No.: 3036156-01-8SOS1 Ligand intermediate-6 is an intermediate for the synthesis of SOS1 ligand and can be used to synthesize PROTACs.
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Sos1 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS23001Sos1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sos1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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2C07
0 ImagesCat. No.: HY-114894CAS No.: 2230185-95-02C07 is a mutant Ras (K-RasM72C, H-RasM72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research.
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NSC-70220 (Standard)
0 ImagesCat. No.: HY-101796RCAS No.: 4551-00-2NSC-70220 (Standard) is the analytical standard of NSC-70220 (HY-101796). This product is intended for research and analytical applications. NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect.
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Sos1 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS16568Sos1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sos1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
