2230185-95-0
Chemical Structure
2C07
- CAS No.: 2230185-95-0
- Formula:C19H25F3N4O2S2
- Molecular Weight:462.55
IUPAC Name: N-(3-((2-(dimethylamino)ethyl)disulfanyl)propyl)-1-(4-methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
InChIKey: RWHKAUSDYJQSDY-UHFFFAOYSA-N
SMILES: O=C(NCCCSSCCN(C)C)C1=C(N(N=C1)C2=CC=C(C=C2)OC)C(F)(F)F
Biological Activity: 2C07 is a mutant Ras (K-RasM72C, H-RasM72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research[1].
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2C07 | 2C07 is a mutant Ras (K-RasM72C, H-RasM72C) inhibitor. 2C07 blocks the activation of PI3K through allosteric Ras modification. 2C07 binds to the modified switch II pocket (S-IIG) of Ras in both GDP- and GTP-bound states, stabilizes the GDP-bound state, disrupts the polar interactions of the canonical GTP-bound state, and inhibits SOS binding and nucleotide exchange. 2C07 can be used in cancer-related research. | |||||||||||||||||||||
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