2758900-76-2
2758900-76-2
Chemical Structure
SOS1-IN-9
- CAS No.: 2758900-76-2
- Formula:C22H28F3N5O
- Molecular Weight:435.49
IUPAC Name: (R)-N-(1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-2-methyl-6-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine
InChIKey: CHKZWOWIGAKWBR-CYBMUJFWSA-N
SMILES: CC1=NC(N[C@@H](C2=CC(N)=CC(C(F)(F)F)=C2)C)=C3CN(CCC3=N1)C4CCOCC4
Biological Activity: SOS1-IN-9 is a potent SOS1 inhibitor with an IC50 of 116.5 nM for SOS1-KRAS G12C (WO2022028506A1, compound 302)[1].
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SOS1-IN-9 | SOS1-IN-9 is a potent SOS1 inhibitor with an IC50 of 116.5 nM for SOS1-KRAS G12C (WO2022028506A1, compound 302). | |||||||||||||||||||||
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References
Keywords
