1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Traxoprodil

Traxoprodil 

Cat. No.: HY-W018061 Purity: 99.43%
Handling Instructions

Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.

For research use only. We do not sell to patients.

Traxoprodil Chemical Structure

Traxoprodil Chemical Structure

CAS No. : 134234-12-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Description

Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.

IC50 & Target

IC50: 10 nM (Neuroprotection)[1]

In Vivo

Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice[1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity[2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures[3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (458.13 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0542 mL 15.2709 mL 30.5418 mL
5 mM 0.6108 mL 3.0542 mL 6.1084 mL
10 mM 0.3054 mL 1.5271 mL 3.0542 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2][3]

Rats[3]

The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.)[3].

Mice[2]

The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

327.42

Formula

C₂₀H₂₅NO₃

CAS No.

134234-12-1

SMILES

OC1(C2=CC=CC=C2)CCN([[email protected]@H](C)[[email protected]@H](O)C3=CC=C(O)C=C3)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.43%

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Cat. No.: HY-W018061