Anagrelide hydrochloride monohydrate
Based on 3 publication(s) in Google Scholar
Anagrelide hydrochloride monohydrate is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride monohydrate, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride monohydrate inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride monohydrate decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride monohydrate is a platelet-lowering agent and plays in the antithrombopoietic action.
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- CAS. Nr.: 823178-43-4
- Formel: C10H10Cl3N3O2
- Molecular Weight:310.56
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Speicherung:
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Publications Citing Use of MedChemExpress (MCE) Anagrelide hydrochloride monohydrate
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Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
PDE3 |
In Vitro
Anagrelide hydrochloride monohydrate potently inhibits the development of marrow megakaryocytes (IC50=26 nM)[1].
Anagrelide (0.05, 0.3, 1 µM; 12-day) hydrochloride monohydrate inhibits only megakaryocytic cell growth not non-megakaryocytic cells[2].
Anagrelide (0.1-10000 nM) hydrochloride monohydrate induces a cytotoxic effect in the GIST882 cell line[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Megakaryocytic and non-megakaryocytic cells
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Concentration:0.05, 0.3, 1 µM
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Incubation Time:12-day
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Result:Inhibited only megakaryocytic cell growth at every concentration tested.
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Cell Line:GIST882 and GIST48 cell line[3]
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Concentration:0.1, 1, 10, 100, 1000, 10000 nM
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Incubation Time:
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Result:Induced a cytotoxic effect in the GIST882 cell line (IC50= 16 nM), but was only weakly active in the GIST48 cell line.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model[3]
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Dosage:5 mg/kg
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Administration:Twice daily; for 10 days
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Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
Chemical Information
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CAS. Nr. 823178-43-4
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Molecular Weight 310.56
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Formel C10H10Cl3N3O2
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SMILES
ClC1=C(CN(C2)C3=NC2=O)C(N3)=CC=C1Cl.O.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Metab
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. [Abstract]2022 Mar 1;34(3):424-440.e7. PMID: 35150639 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Exp Hematol
Purging myeloma cell contaminants and simultaneous expansion of peripheral blood mobilised stem cells. [Abstract]2024 Mar:131:104138. PMID: 38151170
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anagrelide hydrochloride monohydrate Related Classifications
HY-B0523B Related Classifications
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