823178-43-4
Chemical Structure
Anagrelide hydrochloride monohydrate
- CAS No.: 823178-43-4
- Formula:C10H10Cl3N3O2
- Molecular Weight:310.56
IUPAC Name: 6,7-dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride hydrate
InChIKey: YLFXXKJQBOJJIX-UHFFFAOYSA-N
SMILES: ClC1=C(CN(C2)C3=NC2=O)C(N3)=CC=C1Cl.O.Cl
Biological Activity: Anagrelide hydrochloride monohydrate is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride monohydrate, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride monohydrate inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride monohydrate decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride monohydrate is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].
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Anagrelide hydrochloride monohydrate | Anagrelide hydrochloride monohydrate is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM). Anagrelide hydrochloride monohydrate, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride monohydrate inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride monohydrate decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride monohydrate is a platelet-lowering agent and plays in the antithrombopoietic action. | |||||||||||||||||||||
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- [1]. Pescatore SL, et al. Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother. 2000 Mar;1(3):537-46. [Content Brief]
- [2]. Mahajan R, et al. Phosphodiesterase inhibitors and their role in therapeutics[J]. Journal of Research in Medical Education & Ethics, 2013, 3(2): 115-123.
Keywords
