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Art. -Nr.: HY-P991754

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Anti-Mouse TREM2 Antibody (178)

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Anti-Mouse TREM2 Antibody (178) is an antibody targeting mouse TREM2, which blocks the binding of ligands to TREM2 and inhibits TREM2-mediated signaling pathways. Anti-Mouse TREM2 Antibody (178) inhibits the tumor growth of MCA/1956 sarcoma in mice. Anti-Mouse TREM2 Antibody (178) enhances IFNγ production by intratumoral CD8⁺ T cells and TNFα production by intratumoral CD4⁺ T cells. Anti-Mouse TREM2 Antibody (178) can be used in the research of sarcoma, colorectal cancer and breast tumors. The recommended isotype control is Rat IgG2a kappa, Isotype Control (HY-P990679).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.92%

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-Mouse TREM2 Antibody (178) Chemical Structure

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Anti-Mouse TREM2 Antibody (178) Product Recommendations:

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target^[1]

TREM-2

TNF-α

Alle TREM receptor Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

The Anti-Mouse TREM2 Antibody (178) (20 μg/mL; overnight) blocks ligand-induced activation of mouse TREM2 in stably transfected 2B4 reporter cells at a concentration of 20 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse TREM2 Antibody (178) (200 μg per mouse; i.p.; once every 5 days; initiated on day 2 after tumor inoculation) significantly inhibits the growth of MCA/1956 sarcomas in mice. When combined with a suboptimal dose of anti-PD-1, it achieves complete tumor regression, while also reshaping the intratumoral myeloid cell population and enhancing T cell effector functions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (mixed sexes, 8 weeks old at tumor injection, subcutaneous injection of 1×10⁶ MCA/1956 sarcoma cells)^[1]
Dosage:

200 μg/mouse
Administration:

i.p.; every 5 days; starting day 2 after tumor injection
Result:

Significantly reduced MCA/1956 tumor growth compared to control antibody treatment.
Induced complete tumor regression in all treated mice when combined with suboptimal anti-PD-1.
Reduced the frequency of Ly6C⁺MHCII^- and CD64⁺ myeloid subsets at day 10 after tumor injection when combined with suboptimal anti-PD-1.
Reduced the representation of Ly6CᵐᵒʷMHCII^-, CD206⁺, CD63⁺, and CD9⁺ macrophage subsets at day 24, with no change in total macrophage numbers.
Augmented IFNγ production by intratumoral CD8⁺ T cells and TNFα production by intratumoral CD4⁺ T cells via ex vivo stimulation.
Was more effective at reducing tumor growth than constitutive TREM2 deficiency.
Had no off-target effects when administered to Trem2^-/^- mice.

Gene ID

83433 [NCBI]

Accession

Q99NH8

Target

TREM-2

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Anwendung

Flow cytometry; ELISA; in vitro TREM-2 blockade; in vivo TREM-2 blockade 

Chemical Information

Appearance Liquid
Color Colorless to light yellow
SMILES

[Anti-Mouse TREM2 Antibody (178)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Molgora M, et al. TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell. 2020 Aug 20;182(4):886-900.e17. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Anti-Mouse TREM2 Antibody (178)

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Anti-Mouse TREM2 Antibody (178)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Alle TREM receptor Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anti-Mouse TREM2 Antibody (178) Related Classifications

HY-P991754 Related Classifications