Atiprosine
Atiprosine (AY-28228) is an orally effective selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. Atiprosine exhibits antagonistic activity against α2-adrenergic receptors (α1-adrenergic receptor), 5-HT₂ receptors (5-HT₂ receptor), and H₁ receptors (H₁ receptor). The pA2 values for these receptors are 6.04, 6.87, and 7.32 respectively. Atiprosine has antihypertensive and hypotensive effects in rats, dogs, and monkeys. It can be used for research on cardiovascular and mental disorders.
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- CAS. Nr.: 89303-63-9
- Formel: C20H29N3
- Molecular Weight:311.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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α1-adrenergic receptor 8.11 (pA2) |
α2-adrenergic receptor 6.04 (pA2) |
5-HT2 Receptor 6.87 (pA2) |
H1 Receptor 7.32 (pA2) |
Chemical Information
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CAS. Nr. 89303-63-9
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Molecular Weight 311.46
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Formel C20H29N3
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SMILES
CC(C)N1CCN([C@@]2([C@@]1(CCN3C2=C(C4=C3C=CC=C4)C)[H])[H])CC
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Synonyms
AY-28228
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Oshiro G, et al. Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys. J Cardiovasc Pharmacol. 1987 Sep;10(3):341-9. [Content Brief]
[2]. Grimes D, et al. In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound. J Cardiovasc Pharmacol. 1987 Sep;10(3):249-58. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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