HDAC-IN-67
Based on 1 publication(s) in Google Scholar
HDAC-IN-67 (compound 27f) is an HDAC inhibitor against HDAC1 and HDAC6, with IC50 values of 22 nM and 8 nM, respectively. HDAC-IN-67 inhibits cell proliferation and induces cell apoptosis. HDAC-IN-67 exhibits antitumor activity.
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- CAS. Nr.: 2821923-75-3
- Formel: C30H47N5O3
- Molecular Weight:525.73
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Speicherung:
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-67
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Biologische Aktivität
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HDAC6 8 nM (IC50) |
HDAC1 22 nM (IC50) |
HDAC-IN-67 exhibits antiproliferative activity in tumour cells K562, MV4-11, HEL, SU-DHL-2 and WSU-DLCL-2, with IC50 values of 4.42 μM, 0.79 μM, 2.43 μM, 1.05 μM, 1.43 μM, respectively[1].
HDAC-IN-67 induces WSU-DLCL-2 cells apoptosis (10 μM: 91.57%; 5 μM: 77.05%)[1].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562, MV4-11, HEL, SU-DHL-2 and WSU-DLCL-2
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Concentration:5 μM
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Incubation Time:72 h
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Result:Exhibited antiproliferative activity.
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Cell Line:WSU-DLCL-2
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Concentration:5 μM and 10 μM
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Incubation Time:72 h
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Result:Induced WSU-DLCL-2 cells apoptosis in a dose-dependent manner (10 μM: 91.57%; 5 μM: 77.05%).
HDAC-IN-67 (p.o.:10 mg/kg) exhibits low oral bioavailability(F=3.15%)[1].
HDAC-IN-67 (i.p.:50mg/kg once daily for 21 days) demonstrates a moderate in vivo antitumor potency with TGI of 31.5%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female ICR mice/antitumour potency[1]
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Dosage:i.p., 50 mg/kg once a day for 21 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Exhibited in vivo antitumorpotency with TGI of 31.5%.
Chemical Information
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CAS. Nr. 2821923-75-3
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Molecular Weight 525.73
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Formel C30H47N5O3
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SMILES
ONC(CCCCCCC(N1CCN(CC1)CC([C@@H]2CC[C@](C=C)(C)[C@H](C(CN3N=CC=C3)=C)C2)=C)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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