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Art. -Nr.: HY-N21836

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Partricin A

Partricin A is an antimicrobial agent with affinity for ergosterol and cholesterol. Partricin A inhibits growth of fungal species and Trichomonas vaginalis. Partricin A induces hemolysis of rat erythrocytes. Partricin A causes acute toxicity in mice via intraperitoneal or intravenous administration. Partricin A serves as a starting material for synthesis of semisynthetic amide derivatives. Partricin A can be used for the research of fungal infections, trichomonas vaginalis infection.

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CAS. Nr.: 76551-64-9
Formel: C₅₉H₈₆N₂O₁₉
Molecular Weight:1127.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Partricin A Chemical Structure

CAS. Nr.: 76551-64-9

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Beschreibung

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In Vitro

Partricin A (serial dilutions; 24-48 h) inhibits growth of Candida albicans strains LRM 73, LRM 200, and LRM 205 with minimum inhibitory concentrations ranging from 30 ng/mL (24 h, LB) to 120 ng/mL (48 h, SB)^[1].
Partricin A (serial dilutions; 7 h) inhibits 50% of Saccharomyces cerevisiae LRM 167 growth with an IC₅₀ of 2.1 ng/mL after 7 h incubation in liquid medium^[1].
Partricin A (serial dilutions; 24-48 h, 4 days, 5 days) inhibits growth of Mucor sp. LRM 263 (MIC 1.2-2.4 μg/mL), Aspergillus niger LRM 374 (MIC 2.4 μg/mL), and Trichophyton mentagrophytes LRM 176 (MIC 2.4 μg/mL) in solid or liquid culture media^[1].
Partricin A (serial dilutions; 48 h) inhibits growth of Trichomonas vaginalis LRM 415 with an MIC of 0.075 μg/mL after 48 h incubation in semisolid medium^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Partricin A (0.6 mg/kg; i.p.) exhibits high acute toxicity in mice with an i.p. LD₅₀ of 0.6 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD1 (male, 4-5 weeks old, 14-18 g)^[1]
Dosage:

0.6 mg/kg
Administration:

i.p.
Result:

Exhibited an intraperitoneal LD₅₀ of 0.6 mg/kg.

Chemical Information

CAS. Nr. 76551-64-9
Molecular Weight 1127.32
Formel C₅₉H₈₆N₂O₁₉
SMILES

O=C(O[C@H]([C@@H](C)CC[C@@H](O)CC(C1=CC=C(NC)C=C1)=O)[C@@H](C)/C=C/C=C/C=C\C=C/C=C/C=C/C=C/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C3)C[C@H](O)CC(C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@]4(O)C[C@H](O)[C@@H](C(O)=O)[C@H]3O4)=O
Structure Classification
- Antibiotics
Initial Source
- Microorganisms
Streptomyces aureofaciens
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bruzzese T, Rimaroli C, Bonabello A, et al. Amide derivatives of partricin A with potent antifungal activity[J]. European journal of medicinal chemistry, 1996, 31(12): 965-972.

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Molecular Weight Molecular Weight

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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Partricin A

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