HSD17B11 - hydroxysteroid 17-beta dehydrogenase 11 Gene

Also Known as DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51170

About HSD17B11

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,336,515-87,391,188 (from NCBI)

This gene has 7 transcripts (splice variants), 122 orthologues and 25 paralogues. Broad expression in small intestine (RPKM 142.3), duodenum (RPKM 102.8) and 22 other tissues.

Summary

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

HSD17B11 Products (1)

mRNA Protein Name
NM_016245.5 NP_057329.3 estradiol 17-beta-dehydrogenase 11 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
12697717 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables steroid dehydrogenase activity IDA
IDA: Inferred from direct assay
12697717 GOA
Biological Process GO Annotation Evidence References Source
involved in androgen catabolic process IDA
IDA: Inferred from direct assay
12697717 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12697717 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
14741744 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B11 Protein Structure

adh_short

adh_short: short chain dehydrogenase (38 - 203)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

estradiol 17-beta-dehydrogenase 11

  • 17-beta-hydroxysteroid dehydrogenase type XI

HSD17B11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSD17B11 Q8NBQ5 SLC25A46 Homo sapiens Q96AG3
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TVP23B Homo sapiens Q9NYZ1
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 SLC22A18 Homo sapiens Q96BI1
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 LNPEP Homo sapiens Q9UIQ6-2
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 HTATIP2 Homo sapiens Q9BUP3-3
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 RMDN2 Homo sapiens Q96LZ7
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 OTULINL Homo sapiens Q9NUU6
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 NEU1 Homo sapiens Q99519
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 CMTM3 Homo sapiens Q96MX0
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
HSD17B11 Q8NBQ5 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06391 HSD17B11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156735 HSD17B13-IN-2 Inhibitor 99.72% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HSD17B11 MGD MGI:2149821
Rattus norvegicus HSD17B11 RGD RGD:1303235
Bos taurus HSD17B11 VGNC VGNC:29970
Macaca mulatta HSD17B11 VGNC VGNC:73431
Felis catus HSD17B11 VGNC VGNC:62846
Others HSD17B11 NCBI