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Cat. No.: HY-123768

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SCH 350581

(Synonyms: AD-101)

SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes.

For research use only. We do not sell to patients.

CAS No.: 306293-36-7
Formula: C₂₈H₃₇F₃N₄O
Molecular Weight:502.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SCH 350581 Chemical Structure

CAS No.: 306293-36-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes^[1].

All CCR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.03 nM Compound: 2	Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5 Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5	[PMID: 12565973]
U-87MG ATCC	IC₅₀	0.2 nM Compound: 2	Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM	[PMID: 12565973]
U-87MG ATCC	IC₅₀	0.5 nM Compound: 18	Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells	[PMID: 11585438]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 306293-36-7
Molecular Weight 502.61
Formula C₂₈H₃₇F₃N₄O
SMILES

O=C(C1=C(C)C=CN=C1C)N2CCC(N3C[C@H](C)N([C@H](C4=CC=C(C(F)(F)F)C=C4)C)CC3)(C)CC2
Synonyms

AD-101
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsamis F, et al. Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. J Virol. 2003 May;77(9):5201-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Purity & Documentation
References

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SCH 350581

All CCR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SCH 350581 Related Classifications

HY-123768 Related Classifications