WHI-P258 (Standard)
WHI-P258 (Standard) is the analytical standard of WHI-P258 (HY-108419). This product is intended for research and analytical applications. WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM.
For research use only. We do not sell to patients.
- CAS No.: 21561-09-1
- Formula: C16H15N3O2
- Molecular Weight:281.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 21561-09-1
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Molecular Weight 281.31
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Formula C16H15N3O2
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SMILES
COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [Content Brief]
[2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WHI-P258 (Standard) Related Classifications
HY-108419R Related Classifications
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