21561-09-1
21561-09-1
Chemical Structure
WHI-P258
- CAS No.: 21561-09-1
- Formula:C16H15N3O2
- Molecular Weight:281.31
IUPAC Name: 6,7-dimethoxy-N-phenylquinazolin-4-amine
InChIKey: MJKCGAHOCZLYDG-UHFFFAOYSA-N
SMILES: COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC
Biological Activity: WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].
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WHI-P258 | 99.91% | WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM. | ||||||||||||||||||||
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WHI-P258 (Standard) | ≥98% | WHI-P258 (Standard) is the analytical standard of WHI-P258 (HY-108419). This product is intended for research and analytical applications. WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM. | ||||||||||||||||||||
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References
- [1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [Content Brief]
- [2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22. [Content Brief]
Keywords
