1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Benzolamide

Benzolamide (Synonyms: CL11366)

Cat. No.: HY-118467 Purity: 98.07%
Handling Instructions

Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures.

For research use only. We do not sell to patients.

Benzolamide Chemical Structure

Benzolamide Chemical Structure

CAS No. : 3368-13-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].

IC50 & Target

Ki: 15 nM (hCA I), 9 nM (hCA II), 94 nM (EcoCAγ), 78 nM (VchCAγ), 54 nM (CAS3)[1][2]

In Vitro

Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1].
Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Wistar Han rats (11-day-old)[3]
Dosage: 90 µmol/kg
Administration: A single i.p.
Result: Induced a fast brain acidosis of a comparable magnitude.
Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.
Molecular Weight

320.37

Formula

C₈H₈N₄O₄S₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (780.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1214 mL 15.6070 mL 31.2139 mL
5 mM 0.6243 mL 3.1214 mL 6.2428 mL
10 mM 0.3121 mL 1.5607 mL 3.1214 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Benzolamide
Cat. No.:
HY-118467
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