3368-13-6
3368-13-6
Chemical Structure
Benzolamide
Synonym(s): CL11366
- CAS No.: 3368-13-6
- Formula:C8H8N4O4S3
- Molecular Weight:320.37
IUPAC Name: 5-(phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide
InChIKey: PWDGTQXZLNDOKS-UHFFFAOYSA-N
SMILES: O=S(C1=NN=C(S1)NS(=O)(C2=CC=CC=C2)=O)(N)=O
Biological Activity: Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].
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Benzolamide | 99.59% | Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures. | ||||||||||||||||||||
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Benzolamide (Standard) | ≥98% | Benzolamide (Standard) is the analytical standard of Benzolamide. This product is intended for research and analytical applications. Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures. | ||||||||||||||||||||
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References
- [1]. Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554. [Content Brief]
- [2]. Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036. [Content Brief]
- [3]. Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27. [Content Brief]
Keywords
