2. Immunology/Inflammation
  3. COX
  4. Bis[2-(4-hydroxyphenylthio)ethoxy]methane

Bis[2-(4-hydroxyphenylthio)ethoxy]methane  (Synonyms: DD-70)

Cat. No.: HY-W744923 Purity: 99.30%
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Bis[2-(4-hydroxyphenylthio) ethoxy]methane (DD-70) is a Bisphenol A (HY-18260) substitute and a COX-1 inhibitor. Bis[2-(4-hydroxyphenylthio) ethoxy]methane blocks platelet aggregation induced by Arachidonic acid (HY-109590) and U-46619 (HY-108566). Bis[2-(4-hydroxyphenylthio) ethoxy]methane alters hemostatic function. Bis[2-(4-hydroxyphenylthio) ethoxy]methane reduces embryonic survival rate, decreases embryonic mass and increases gallbladder mass in chicken embryos.

For research use only. We do not sell to patients.

Bis[2-(4-hydroxyphenylthio)ethoxy]methane

Bis[2-(4-hydroxyphenylthio)ethoxy]methane Chemical Structure

CAS No. : 93589-69-6

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10 mM * 1 mL in DMSO
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Bis[2-(4-hydroxyphenylthio)ethoxy]methane Related Antibodies

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Description

Bis[2-(4-hydroxyphenylthio) ethoxy]methane (DD-70) is a Bisphenol A (HY-18260) substitute and a COX-1 inhibitor. Bis[2-(4-hydroxyphenylthio) ethoxy]methane blocks platelet aggregation induced by Arachidonic acid (HY-109590) and U-46619 (HY-108566). Bis[2-(4-hydroxyphenylthio) ethoxy]methane alters hemostatic function. Bis[2-(4-hydroxyphenylthio) ethoxy]methane reduces embryonic survival rate, decreases embryonic mass and increases gallbladder mass in chicken embryos[1][2][3].

IC50 & Target[1]

COX-1

 

In Vitro

Bis[2-(4-hydroxyphenylthio) ethoxy]methane (4 h) exhibits low acute toxicity toward red blood cells, with a TC50 greater than 500 μM[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0-80 μM; 3 min) potently inhibits arachidonic acid (HY-109590)-induced platelet aggregation in whole blood, with an IC50 of 5.0 µM[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (20-80 μM; 3 min) inhibits U-46619 (HY-108566)-induced platelet aggregation in whole blood in a concentration-dependent manner[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0.1-100 μM; 3 min) potently inhibits the production of Thromboxane A2 from Arachidonic acid in platelet-rich plasma[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (1-100 μM) potently inhibits recombinant ovine cyclooxygenase 1, with greater efficacy than Acetylsalicylic acid (HY-14654), and reaches maximum inhibitory effect at concentrations ≥10 μM[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0.1-40 μM, combined with 30 μM ASA; 3 min) dose-dependently enhances the antiplatelet effect of Acetylsalicylic acid (HY-14654) against Arachidonic acid-induced platelet aggregation in whole blood[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0.01-300 μM; 24 h) exhibits higher cytotoxicity towards chicken embryo hepatocytes than Bisphenol A (HY-18260), with an LC50 of 32.9 μM following 24 h of exposure[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis[2-(4-hydroxyphenylthio)ethoxy]methane Related Antibodies
In Vivo

DD-70 (1.09-88.2 µg/g; air sac injection; single administration on day 0) reduces the survival rate of mid-incubation chicken embryos to 63% at doses of 40.9 µg/g and 88.2 µg/g, decreases embryo quality at the dose of 88.2 µg/g, increases gallbladder weight at the dose of 40.9 µg/g, and dysregulates hepatic genes involved in lipid homeostasis and estrogen response.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Domestic chicken (fertilized, unincubated eggs)[2]
Dosage: 1.09 µg/g, 7.74 µg/g, 40.9 µg/g, 88.2 µg/g
Administration: air cell injection; single dose on day 0
Result: Reduced mid-incubation viability to 63% for 40.9 µg/g and 88.2 µg/g doses (vs. 94% for control).
Maintained 100% mid-incubation viability for 1.09 µg/g dose and 96% for 7.74 µg/g dose.
Achieved 100% term viability for 1.09 µg/g and 7.74 µg/g doses, 83% for 40.9 µg/g dose, and 89% for 88.2 µg/g dose.
Decreased embryonic mass at term at 88.2 µg/g dose.
Increased gallbladder mass to 0.033 g at 40.9 µg/g dose (vs. 0.022 g for control; p < 0.05).
Upregulated fibroblast growth factor 19 (FGF19) 6.81-log2 fold at mid-incubation and 3.53-log2 fold at term at 88.2 µg/g dose.
Downregulated apovitellenin-1 (APOV1) 4.04-log2 fold at mid-incubation at 88.2 µg/g dose.
Upregulated avidin (AVD) 1.54-log2 fold and carnitine O-palmitoyltransferase 1 (CPT1A) 1.30-log2 fold at term at 88.2 µg/g dose.
Detected embryonic homogenate concentrations of 4.04 µg/g at mid-incubation and 0.10 µg/g at term for 7.74 µg/g dose, indicating metabolism.
Molecular Weight

352.47

Formula

C17H20O4S2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC1=CC=C(C=C1)SCCOCOCCSC2=CC=C(C=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8371 mL 14.1856 mL 28.3712 mL
5 mM 0.5674 mL 2.8371 mL 5.6742 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8371 mL 14.1856 mL 28.3712 mL 70.9280 mL
5 mM 0.5674 mL 2.8371 mL 5.6742 mL 14.1856 mL
10 mM 0.2837 mL 1.4186 mL 2.8371 mL 7.0928 mL
15 mM 0.1891 mL 0.9457 mL 1.8914 mL 4.7285 mL
20 mM 0.1419 mL 0.7093 mL 1.4186 mL 3.5464 mL
25 mM 0.1135 mL 0.5674 mL 1.1348 mL 2.8371 mL
30 mM 0.0946 mL 0.4729 mL 0.9457 mL 2.3643 mL
40 mM 0.0709 mL 0.3546 mL 0.7093 mL 1.7732 mL
50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4186 mL
60 mM 0.0473 mL 0.2364 mL 0.4729 mL 1.1821 mL
80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8866 mL
100 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7093 mL
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Bis[2-(4-hydroxyphenylthio)ethoxy]methane Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Bis[2-(4-hydroxyphenylthio)ethoxy]methane93589-69-6DD-70DD70DD 70COXCyclooxygenasechicken embryosU-46619antiplatelet activityPAFdithiothreitolarachidonic acidovinecyclooxygenase 1platelet aggregationcollagenInhibitorinhibitorinhibit

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