Bis[2-(4-hydroxyphenylthio)ethoxy]methane
Based on 1 Customer Validation
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (DD-70) is a Bisphenol A (HY-18260) substitute and a COX-1 inhibitor. Bis[2-(4-hydroxyphenylthio) ethoxy]methane blocks platelet aggregation induced by Arachidonic acid (HY-109590) and U-46619 (HY-108566). Bis[2-(4-hydroxyphenylthio) ethoxy]methane alters hemostatic function. Bis[2-(4-hydroxyphenylthio) ethoxy]methane reduces embryonic survival rate, decreases embryonic mass and increases gallbladder mass in chicken embryos.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 93589-69-6
- Formula: C17H20O4S2
- Molecular Weight:352.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
![Bis[2-(4-hydroxyphenylthio)ethoxy]methane Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w744923.gif "Click to View Bis[2-(4-hydroxyphenylthio)ethoxy]methane Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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COX-1 |
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (4 h) exhibits low acute toxicity toward red blood cells, with a TC50 greater than 500 μM[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0-80 μM; 3 min) potently inhibits arachidonic acid (HY-109590)-induced platelet aggregation in whole blood, with an IC50 of 5.0 µM[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (20-80 μM; 3 min) inhibits U-46619 (HY-108566)-induced platelet aggregation in whole blood in a concentration-dependent manner[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0.1-100 μM; 3 min) potently inhibits the production of Thromboxane A2 from Arachidonic acid in platelet-rich plasma[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (1-100 μM) potently inhibits recombinant ovine cyclooxygenase 1, with greater efficacy than Acetylsalicylic acid (HY-14654), and reaches maximum inhibitory effect at concentrations ≥10 μM[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0.1-40 μM, combined with 30 μM ASA; 3 min) dose-dependently enhances the antiplatelet effect of Acetylsalicylic acid (HY-14654) against Arachidonic acid-induced platelet aggregation in whole blood[1].
Bis[2-(4-hydroxyphenylthio) ethoxy]methane (0.01-300 μM; 24 h) exhibits higher cytotoxicity towards chicken embryo hepatocytes than Bisphenol A (HY-18260), with an LC50 of 32.9 μM following 24 h of exposure[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic chicken (fertilized, unincubated eggs)[2]
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Dosage:1.09 µg/g, 7.74 µg/g, 40.9 µg/g, 88.2 µg/g
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Administration:air cell injection; single dose on day 0
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Result:Reduced mid-incubation viability to 63% for 40.9 µg/g and 88.2 µg/g doses (vs. 94% for control).
Maintained 100% mid-incubation viability for 1.09 µg/g dose and 96% for 7.74 µg/g dose.
Achieved 100% term viability for 1.09 µg/g and 7.74 µg/g doses, 83% for 40.9 µg/g dose, and 89% for 88.2 µg/g dose.
Decreased embryonic mass at term at 88.2 µg/g dose.
Increased gallbladder mass to 0.033 g at 40.9 µg/g dose (vs. 0.022 g for control; p < 0.05).
Upregulated fibroblast growth factor 19 (FGF19) 6.81-log2 fold at mid-incubation and 3.53-log2 fold at term at 88.2 µg/g dose.
Downregulated apovitellenin-1 (APOV1) 4.04-log2 fold at mid-incubation at 88.2 µg/g dose.
Upregulated avidin (AVD) 1.54-log2 fold and carnitine O-palmitoyltransferase 1 (CPT1A) 1.30-log2 fold at term at 88.2 µg/g dose.
Detected embryonic homogenate concentrations of 4.04 µg/g at mid-incubation and 0.10 µg/g at term for 7.74 µg/g dose, indicating metabolism.
Chemical Information
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CAS No. 93589-69-6
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Appearance Solid
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Molecular Weight 352.47
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Formula C17H20O4S2
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Color White to light yellow
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SMILES
OC1=CC=C(C=C1)SCCOCOCCSC2=CC=C(C=C2)O
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Synonyms
DD-70
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (283.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Handling Instructions (2659 KB)
References
[2]. Sharin T, et al. Effects of two Bisphenol A replacement compounds, 1,7-bis (4-hydroxyphenylthio)-3,5-dioxaheptane and Bisphenol AF, on development and mRNA expression in chicken embryos. Ecotoxicol Environ Saf. 2021 Jun 1;215:112140. [Content Brief]
[3]. Sharin T, et al. Toxicity Screening of Bisphenol A Replacement Compounds: Cytotoxicity and mRNA Expression in Primary Hepatocytes of Chicken and Double-Crested Cormorant. Environ Toxicol Chem. 2021 May;40(5):1368-1378. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8371 mL | 14.1856 mL | 28.3712 mL | 70.9280 mL |
| 5 mM | 0.5674 mL | 2.8371 mL | 5.6742 mL | 14.1856 mL | |
| 10 mM | 0.2837 mL | 1.4186 mL | 2.8371 mL | 7.0928 mL | |
| 15 mM | 0.1891 mL | 0.9457 mL | 1.8914 mL | 4.7285 mL | |
| 20 mM | 0.1419 mL | 0.7093 mL | 1.4186 mL | 3.5464 mL | |
| 25 mM | 0.1135 mL | 0.5674 mL | 1.1348 mL | 2.8371 mL | |
| 30 mM | 0.0946 mL | 0.4729 mL | 0.9457 mL | 2.3643 mL | |
| 40 mM | 0.0709 mL | 0.3546 mL | 0.7093 mL | 1.7732 mL | |
| 50 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL | 1.4186 mL | |
| 60 mM | 0.0473 mL | 0.2364 mL | 0.4729 mL | 1.1821 mL | |
| 80 mM | 0.0355 mL | 0.1773 mL | 0.3546 mL | 0.8866 mL | |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2837 mL | 0.7093 mL |
Bis[2-(4-hydroxyphenylthio)ethoxy]methane Related Classifications
HY-W744923 Related Classifications
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