1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-8

BMS-8 

Cat. No.: HY-116274
Handling Instructions

BMS-8 inhibits the PD-1/PD-L1 interaction with IC50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.

For research use only. We do not sell to patients.

BMS-8 Chemical Structure

BMS-8 Chemical Structure

CAS No. : 1675201-90-7

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Description

BMS-8 inhibits the PD-1/PD-L1 interaction with IC50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1[1].

In Vitro

BMS-8 tends to have a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

494.42

Formula

C₂₇H₂₈BrNO₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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BMS-8
Cat. No.:
HY-116274
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