1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-8

BMS-8 

Cat. No.: HY-116274 Purity: ≥98.0%
Handling Instructions

BMS-8 inhibits the PD-1/PD-L1 interaction with IC50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.

For research use only. We do not sell to patients.

BMS-8 Chemical Structure

BMS-8 Chemical Structure

CAS No. : 1675201-90-7

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Description

BMS-8 inhibits the PD-1/PD-L1 interaction with IC50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1[1].

In Vitro

BMS-8 tends to have a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

494.42

Formula

C27H28BrNO3

CAS No.
SMILES

CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC=C(C=C3Br)CN4CCCCC4C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (168.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0226 mL 10.1129 mL 20.2257 mL
5 mM 0.4045 mL 2.0226 mL 4.0451 mL
10 mM 0.2023 mL 1.0113 mL 2.0226 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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BMS-8
Cat. No.:
HY-116274
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