1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-1

BMS-1 (Synonyms: PD-1/PD-L1 inhibitor 1)

Cat. No.: HY-19991 Purity: 99.61%
Handling Instructions

BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM).

For research use only. We do not sell to patients.

BMS-1 Chemical Structure

BMS-1 Chemical Structure

CAS No. : 1675201-83-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 228 In-stock
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25 mg USD 456 In-stock
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50 mg USD 660 In-stock
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100 mg USD 1056 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM)[1][2].

IC50 & Target

PD1-PDL1[1]

In Vitro

Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1[1]. BMS-1, a small-molecule immune checkpoint inhibitor of PD-1/PD-L1, can be used as a therapeutic strategy for tumor immunotherapy[2].

Cell Cytotoxicity Assay[1]

Cell Line: NK cells and HepG2 cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Disturbed the interaction between PD-1 and PD-L1.
In Vivo

BMS-1 (500 μg/mL; 100 μL; i.p.) significantly slows down tumor growth and prolongs the survival rates in BALB/c mice[3].

Animal Model: BALB/c mice[3]
Dosage: 500 μg/mL; 100 μL
Administration: I.p.
Result: Administration significantly slowed down tumor growth and prolonged the survival rates.
Molecular Weight

475.58

Formula

C₂₉H₃₃NO₅

CAS No.

1675201-83-8

SMILES

O=C([[email protected]]1N(CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC)CCCC1)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 29 mg/mL (60.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1027 mL 10.5135 mL 21.0270 mL
5 mM 0.4205 mL 2.1027 mL 4.2054 mL
10 mM 0.2103 mL 1.0513 mL 2.1027 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.61%

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