PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats

  • Sci Rep. 2025 Dec 17. doi: 10.1038/s41598-025-31618-6.
Honglei Zhang  #  1 ,  Yi Wang  #  1 ,  Shiwei Wen  2 ,  Jing Li  3
Affiliations
  • 1. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 149 Dalian Street, Zunyi, 563000, Guizhou, China.
  • 2. Department of Operating Room, Affiliated Hospital of Zunyi Medical University, 149 Dalian Street, Zunyi, 563000, Guizhou, China.
  • 3. Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 149 Dalian Street, Zunyi, 563000, Guizhou, China. [email protected].
  • # Contributed equally.
PMID: 41408237 DOI: 10.1038/s41598-025-31618-6
Keywords
Acute postoperative pain; Neuroinflammation; PD-1; PD-L1; Treatment.
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