1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-1001 hydrochloride

BMS-1001 hydrochloride 

Cat. No.: HY-120635
Handling Instructions

BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells.

For research use only. We do not sell to patients.

BMS-1001 hydrochloride Chemical Structure

BMS-1001 hydrochloride Chemical Structure

CAS No. : 2113650-04-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 292 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 355 In-stock
Estimated Time of Arrival: December 31
25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2176 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells[1].

IC50 & Target

PD-L1/PD-1[1].

In Vitro

BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes[1].

Molecular Weight

631.11

Formula

C₃₅H₃₅ClN₂O₇

CAS No.

2113650-04-5

SMILES

OC[[email protected]@H](NCC1=CC(C)=C(C=C1OCC2=CC=CC(C#N)=C2)OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C(O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (19.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5845 mL 7.9225 mL 15.8451 mL
5 mM 0.3169 mL 1.5845 mL 3.1690 mL
10 mM 0.1585 mL 0.7923 mL 1.5845 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (1.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (1.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BMS-1001BMS1001BMS 1001PD-1/PD-L1PD-1/Programmed death-ligand 1immunecheckpointICBlowtoxicityInhibitorinhibitorinhibit

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Product name:
BMS-1001 hydrochloride
Cat. No.:
HY-120635
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