HOXC13 - homeobox C13 Gene

Also Known as HOX3; ECTD9; HOX3G

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3229

About HOXC13

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,938,831-53,946,544 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues, 42 paralogues and is associated with 50 phenotypes. Biased expression in skin (RPKM 1.8), testis (RPKM 0.2) and 1 other tissue.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008]

HOXC13 Products (1)

mRNA	Protein	Name
NM_017410.3	NP_059106.2	homeobox protein Hox-C13

HOXC13 Protein Structure

HoxA13_N

Homeobox

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
homeobox protein Hox-C13	NUP98/HOXC13

HOXC13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOXC13	P31276	NFATC1	Homo sapiens	O95644	TAP	25609649
Intra	HOXC13	P31276	ELF1	Homo sapiens	P32519	Anti Tag CoIP	18692240

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ectodermal Dysplasia 9, Hair/Nail Type	ECTD9 Ectodermal Dysplasia 9 Dysplasia, Ectodermal, Type 9, Hair/Nail
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
Lacrimal Duct Obstruction	Blocked Lacrimal Canaliculus Obstruction Of Lacrimal Canaliculus Obstruction Of Lacrimal Ducts
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Ectodermal Dysplasia 5, Hair/Nail Type	ECTD5 Ectodermal Dysplasia 5
Ectodermal Dysplasia 6, Hair/Nail Type	ECTD6 Ectodermal Dysplasia 6
Ectodermal Dysplasia 7, Hair/Nail Type	ECTD7 Ectodermal Dysplasia 7 Dysplasia, Ectodermal, Type 7, Hair/Nail
Hypotrichosis
Skin Pilomatrix Carcinoma	Pilomatrix Carcinoma Of Skin Malignant Pilomatricoma Pilomatricoma, Malignant
Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Guttmacher Syndrome Preaxial Deficiency, Postaxial Polydactyly And Hypospadias Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome GUTTS
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Hand-Foot-Genital Syndrome	Hand-Foot-Uterus Syndrome Hfgs Hfg Syndrome Hfu Syndrome HFG Hfu Hand Foot Uterus Syndrome Hand Foot Genital Syndrome
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy	Winged Helix Deficiency Alymphoid Cystic Thymic Dysgenesis Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome Pignata Guarino Syndrome TIDAND T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency Severe Combined Immunodeficiency Due To Foxn1 Deficiency Foxn1 Deficiency Nude/Scid Nude/Severe Combined Immunodeficiency Scid Due To Foxn1 Deficiency Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
Hair Follicle Neoplasm	Hair Matrix Neoplasm Hair Matrix Tumour
Vertical Talus, Congenital	Congenital Vertical Talus CVT Congenital Convex Pes Valgus Rocker-Bottom Foot Deformity Vertical Talus Pes Valgus, Congenital Convex Congenital Convex Foot Congenital Rocker-Bottom Foot Rocker Bottom Foot Flatfoot Rocker-Bottom Foot Charcot-Marie-Tooth Disease, Foot Deformity Of
Hypotrichosis 4	HYPT4 Marie Unna Hereditary Hypotrichosis 1 Muhh1 Hypotrichosis, Marie Unna Type, 1 Hypotrichosis Marie Unna 1 Marie Unna Hereditary Hypotrichosis Type 1 Hypotrichosis, Hereditary, Marie Unna Type, 1 Hypotrichosis, Type 4
Pilomatrixoma	Pilomatricoma PTR Epithelioma Calcificans Of Malherbe Benign Pilomatricoma Calcifying Epithelioma Of Malherbe Pilomatricoma, Somatic Benign Pilomatrixoma Malherbe Calcifying Epithelioma
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06316	HOXC13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOXC13	MGD	MGI:99560
Rattus norvegicus	HOXC13	RGD	RGD:1563984
Canis familiaris	HOXC13	VGNC	VGNC:41758
Macaca mulatta	HOXC13	VGNC	VGNC:108348
Bos taurus	HOXC13	VGNC	VGNC:29924
Others	HOXC13	NCBI