EXOSC5 - exosome component 5 Gene

Also Known as p12B; CABAC; RRP46; RRP41B; Rrp46p; hRrp46p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56915

About EXOSC5

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,386,374-41,397,359 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 8.8), ovary (RPKM 8.2) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in DNA deamination and exonucleolytic catabolism of deadenylated mRNA. Acts upstream of or within defense response to virus. Located in nucleolus; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC5 Products (1)

mRNA Protein Name
NM_020158.4 NP_064543.3 exosome complex component RRP46

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables RNA exonuclease activity IDA
IDA: Inferred from direct assay
17174896 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11812149 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA deamination IDA
IDA: Inferred from direct assay
21255825 GOA
involved in RNA catabolic process IDA
IDA: Inferred from direct assay
17174896 GOA
involved in RNA processing IDA
IDA: Inferred from direct assay
17174896 GOA
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
21791617 GOA
involved in mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
11782436 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
20531386 GOA
located in euchromatin IMP
IMP: Inferred from mutant phenotype
20699273 GOA
part of exosome (RNase complex) IDA
IDA: Inferred from direct assay
20531389 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
20531386 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20531386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOSC5 Protein Structure

RNase_PH

RNase_PH: 3' exoribonuclease family, domain 1 (28 - 147)

RNase_PH_C

RNase_PH_C: 3' exoribonuclease family, domain 2 (151 - 215)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

exosome complex component RRP46

  • chronic myelogenous leukemia tumor antigen 28

EXOSC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXOSC5 Q9NQT4 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra
EXOSC5 Q9NQT4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 DOCK8 Homo sapiens Q8NF50-2
Y2H Prey Pooling
25416956
Intra
EXOSC5 Q9NQT4 DOCK8 Homo sapiens Q8NF50-2
Validated Y2H
25416956
Intra
EXOSC5 Q9NQT4 DOCK8 Homo sapiens Q8NF50-2
Y2H Array
25416956
Intra
EXOSC5 Q9NQT4 BORCS6 Homo sapiens Q96GS4
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 BORCS6 Homo sapiens Q96GS4
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 ZNF792 Homo sapiens Q3KQV3
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ZNF792 Homo sapiens Q3KQV3
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 FH Homo sapiens P07954
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 FH Homo sapiens P07954
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
EXOSC5 Q9NQT4 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
EXOSC5 Q9NQT4 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 SHISA6 Homo sapiens Q6ZSJ9
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 SHISA6 Homo sapiens Q6ZSJ9
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ACOT11 Homo sapiens Q8WXI4-2
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ACOT11 Homo sapiens Q8WXI4-2
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 LRMDA Homo sapiens A0A087WWI0
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 LRMDA Homo sapiens A0A087WWI0
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Validated Y2H
25416956
Intra
EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Array
25416956
Intra
EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
25416956
Intra
EXOSC5 Q9NQT4 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
EXOSC5 Q9NQT4 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
TAP
24981860
Intra
EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
26496610
Intra
EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
21255825
Intra
EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
33961781
Intra
EXOSC5 Q9NQT4 EXOSC10 Homo sapiens Q01780
Y2H
15231747
Intra
EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Y2H
12419256
Intra
EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
21255825
Intra
EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
TAP
24981860
Intra
EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Y2H
15231747
Intra
EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
33961781
Intra
EXOSC5 Q9NQT4 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
26496610
Intra
EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H
12419256
Intra
EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H Array
19060904
Intra
EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H
11812149
Intra
EXOSC5 Q9NQT4 EXOSC1 Homo sapiens Q9Y3B2
Y2H
15231747
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Anti Tag CoIP
26496610
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Array
25416956
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H
12419256
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Anti Tag CoIP
33961781
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H
15231747
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
Y2H Array
31515488
Intra
EXOSC5 Q9NQT4 EXOSC8 Homo sapiens Q96B26
TAP
24981860
Intra
EXOSC5 Q9NQT4 MTMR3 Homo sapiens Q13615
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 MTMR3 Homo sapiens Q13615
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 SPTA1 Homo sapiens P02549
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 SPTA1 Homo sapiens P02549
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 NKAPD1 Homo sapiens Q6ZUT1
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 NKAPD1 Homo sapiens Q6ZUT1
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 HOXC4 Homo sapiens P09017
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 HOXC4 Homo sapiens P09017
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ZNF420 Homo sapiens Q8TAQ5
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 ZNF420 Homo sapiens Q8TAQ5
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
EXOSC5 Q9NQT4 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 PEG10 Homo sapiens Q86TG7-2
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 PEG10 Homo sapiens Q86TG7-2
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 SNW1 Homo sapiens Q13573
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 MYLIP Homo sapiens Q8WY64
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 MYLIP Homo sapiens Q8WY64
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 FCHO1 Homo sapiens O14526
Y2H Array
31515488
Intra
EXOSC5 Q9NQT4 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra
EXOSC5 Q9NQT4 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
EXOSC5 Q9NQT4 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra
EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
EXOSC5 Q9NQT4 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
EXOSC5 Q9NQT4 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 LCA5L Homo sapiens O95447
Y2H Array
32296183
Intra
EXOSC5 Q9NQT4 LCA5L Homo sapiens O95447
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
EXOSC5 Q9NQT4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross
EXOSC5 Q9NQT4 Zc3hav1 Rattus norvegicus Q8K3Y6
Anti Bait CoIP
22407013
Cross
EXOSC5 Q9NQT4 Zc3hav1 Rattus norvegicus Q8K3Y6
Pull Down
17185417
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebellar Ataxia, Brain Abnormalities, And Cardiac Conduction Defects

  • CABAC
Cerebellar Hypoplasia
Pontocerebellar Hypoplasia, Type 1c

  • PCH1C

  • Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

  • Pontocerebellar Hypoplasia Type 1c

  • Pontocerebellar Hypoplasia 1c

  • Doid:0112334

  • Hypoplasia, Pontocerebellar, Type 1c
Cat-Scratch Disease

  • Cat Scratch Disease

  • Benign Lymphoreticulosis

  • Cat Scratch Fever

  • Debre'S Syndrome

  • Bartonellosis Due To Bartonella Henselae Infection

  • Debre-Mollaret Syndrome

  • Foshay-Mollaret Cat Scratch Fever

  • Oroya Fever

  • Cat-Scratch Fever

  • Benign Inoculation Lymphoreticulosis

  • Catscratch Disease Or Fever

  • Csd - [Cat Scratch Disease]

  • Nonbacterial Regional Lymphadenitis

  • Rochalimaea Henselae Infection
Pontocerebellar Hypoplasia, Type 1b

  • Pontocerebellar Hypoplasia Type 1b

  • PCH1B

  • Pontocerebellar Hypoplasia 1b

  • Hypoplasia, Pontocerebellar, Type 1b
Trichohepatoenteric Syndrome 1

  • Trichohepatoenteric Syndrome

  • Syndromic Diarrhea

  • Tricho-Hepato-Enteric Syndrome

  • Sd/The

  • Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

  • THES1

  • Phenotypic Diarrhea

  • Thes

  • Phenotypic Diarrhea Of Infancy

  • Diarrhea, Syndromic

  • Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

  • Intractable Diarrhea With Phenotypic Anomalies

  • Syndromatic Diarrhea

  • Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1e

  • Pontocerebellar Hypoplasia Type 1

  • PCH1E

  • Norman Disease

  • Pch1

  • Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

  • Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

  • Pontocerebellar Hypoplasia Type 1e

  • Pontocerebellar Hypoplasia 1e

  • Doid:0112322

  • Doid:0112330
Bartonellosis

  • Bartonella Infections

  • Bartonella Infectious Disease

  • Bartonelliasis

  • Rochalimaea Infection

  • Bartonellosis, Unspecified
Pontocerebellar Hypoplasia

  • Pch

  • Congenital Pontocerebellar Hypoplasia

  • Opch

  • Hypoplasia, Pontocerebellar

  • Pontoneocerebellar Hypoplasia

  • Nonsyndromic Pontocerebellar Hypoplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04601 EXOSC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EXOSC5 VGNC VGNC:28660
Rattus norvegicus EXOSC5 RGD RGD:1307861
Canis familiaris EXOSC5 VGNC VGNC:40526
Macaca mulatta EXOSC5 VGNC VGNC:72331
Mus musculus EXOSC5 MGD MGI:107889
Others EXOSC5 NCBI