ZNF420 - zinc finger protein 420 Gene

Also Known as APAK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147923

Summary

The protein encoded by this gene is a KRAB-type Zinc Finger Protein that negatively-regulates p53-mediated Apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates Apoptosis. [provided by RefSeq, Jul 2016]
Ubiquitous expression in testis (RPKM 3.6), ovary (RPKM 3.4) and 25 other tissues.

ZNF420 Products (1)

mRNA Protein Name
NG_051212.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20713054 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF420 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF420 Q8TAQ5 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
ZNF420 Q8TAQ5 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
ZNF420 Q8TAQ5 TP53 Homo sapiens P04637
Pull Down
20713054
Intra
ZNF420 Q8TAQ5 TP53 Homo sapiens P04637
Anti Tag CoIP
20713054
Intra
ZNF420 Q8TAQ5 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra
ZNF420 Q8TAQ5 CDKN2A Homo sapiens Q8N726
IF
20713054
Intra
ZNF420 Q8TAQ5 CDKN2A Homo sapiens Q8N726
Pull Down
20713054
Intra
ZNF420 Q8TAQ5 CDKN2A Homo sapiens Q8N726
Anti Tag CoIP
20713054
Intra
ZNF420 Q8TAQ5 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra
ZNF420 Q8TAQ5 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16138 ZNF410 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16139 ZNF423 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16143 ZNF460 Human Pre-designed siRNA Set A Pre-designed Set / Unkown