4-Methoxybiphenyl
Based on 1 Customer Validation
4-Methoxybiphenyl is a cytochrome P450-dependent microsomal monooxygenase system substrate and metabolite precursor. 4-Methoxybiphenyl undergoes O-demethylation to generate 4-hydroxybiphenyl. 4-Methoxybiphenyl undergoes sulphation and glucuronidation conjugation; inhibition of sulphation shifts metabolism toward increased glucuronidation and unconjugated 4-hydroxybiphenyl accumulation. 4-Methoxybiphenyl serves as a model substrate for studying phase II metabolic conjugation pathway balance in rat isolated hepatocytes.
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- CAS No.: 613-37-6
- Formule: C13H12O
- Masse moléculaire:184.24
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
17 μg/mL
Compound: 19
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Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
| HT-29 | IC50 |
45 μg/mL
Compound: 19
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Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
| MCF7 | IC50 |
>100 μg/mL
Compound: 19
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Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
4-Methoxybiphenyl (100 μM; 20 min) metabolism by isolated male Wistar rat hepatocytes produces 4-OHBP via O-demethylation, which is conjugated into sulphate and glucuronide conjugates; inhibition of sulphation (via 50 μM DCNP or sulphate-free medium) significantly increases 4-OHBP glucuronide, unconjugated 4-OHBP, and total 4-OHBP levels, with total 4-OHBP reaching 19.47 nmol/2 × 106 cells/20 min with 50 μM DCNP and 20.01 nmol/2 × 106 cells/20 min in sulphate-free medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 613-37-6
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Appearance Solid
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Masse moléculaire 184.24
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Formule C13H12O
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SMILES
COC1=CC=C(C=C1)C2=CC=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
Références
[1]. Fry JR, et al. Influence of the sulphation inhibitor, 2,6-dichloro-4-nitrophenol, on the production and conjugation, of 4-hydroxybiphenyl generated from 4-methoxybiphenyl by rat isolated hepatocytes. Biochem Pharmacol. 1987 Sep 15;36(18):3090-2. doi: 10.1016/0006-2952(87)90232-2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Methoxybiphenyl Related Classifications
HY-129565 Related Classifications
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